No Liver Toxicity Seen in TRT Study Data Presented at ENDO 2021

The testosterone replacement therapy (TRT) testosterone undecanoate oral capsules shows no evidence of liver toxicity, according to data from a two-year, multi-center study presented at ENDO 2021. Marketed under the brand name JATENZO® by Clarus Therapeutics, Inc., this oral softgel has been commercially available since February 2020 after a March 2019 approval by the U.S....

ENDO 2021 Preview: Steroid Abuse Impacts Testicular Function

Illegal use of anabolic steroids not only has dangerous side effects during use but also can harm men’s testicular function years after they stop abusing steroids, according to a study published in The Journal of Clinical Endocrinology & Metabolism. Anabolic steroids are synthetic forms of testosterone, and their abuse is prevalent among athletes worldwide. Some...

Fertility in Transgender Men: What Do We Know?

In transgender men, what are the consequences of gender-affirming hormonal therapy on fertility? Led by Molly B.  Moravek, MD, MPH, a team of researchers from the Center for Reproductive Medicine, in Ann Arbor, Mich., set out to answer that question as well as summarize the current literature on the topic of transgender men desiring reproduction...

Insulin Sensitivity Improves with Testosterone Therapy in Men with Type 2 Diabetes and Hypogonadism

About a third of men with type 2 diabetes (T2D) also have hypogonadotropic hypogonadism (HH). This comorbidity makes that subgroup more insulin resistant, with increased adiposity and less lean mass, according to research published recently in The Journal of Clinical Endocrinology & Metabolism. A team led by Paresh Dandona, BSc, MB, BS, DPhil, FRCP, of...

Study Data Helps Refine Testosterone Deficiency Definition and Establish Target Levels for Lifestyle Interventions

As men age, testosterone levels decrease, but current guidelines recommend testing in symptomatic men only, and there has been a lack of consensus about what point that decrease becomes a deficiency. Healthy aging men have been presumed to have higher serum testosterone levels than their counterparts with obesity, smoking history, or associated comorbidities, but large-scale...

Testosterone Supplementation in Healthy Men with Severe Short-Term Energy Deficit Prevents Increase in Circulating Ghrelin without Suppressing Appetite

Testosterone supplementation prevents an increase in circulating ghrelin but does not appear to affect appetite or energy intake in healthy men who are suffering from a severe, short-term energy deficit, according to a study recently published in the Journal of the Endocrine Society. Researchers led by J. Philip Karl, PhD, RD, and Stefan M. Pasiakos,...


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