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Semaglutide Reduces Excess Body Fat in People with Obesity

Findings suggest drug has potential to reduce risk of heart disease, diabetes, and stroke. In adults with obesity or overweight, weekly treatment with the glucagon-like peptide 1 (GLP1) receptor agonist semaglutide leads to reduced excess body fat and increased lean body mass, according to an industry-sponsored study presented virtually at ENDO 2021. “Our findings suggest...
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Mighty Mouse: Could a Part of the Brain Unlock the Key to Combatting Obesity?

A new mouse study shows promise in addressing the ongoing worldwide obesity epidemic. By targeting a specific brain molecule, researchers could be on the path to a therapy that would potentially enable patients to reduce calories while increasing exercise levels. If Constantine A. Stratakis, MD, DSci, PhD, had his way, clinicians could soon offer their...
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Researchers Develop First-in-Class Humanized Antibody Targeting Bone and Fat

A treatment for obesity and osteoporosis could be on the horizon as Mount Sinai researchers have developed a first-in-class humanized antibody to the follicle-stimulating hormone (FSH) that will reduce body fat, increase bone mass, enhance metabolism, and lower cholesterol. The antibody has the potential to prevent and treat obesity, osteoporosis, and hypercholesterolemia — diseases that...
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Cause & Effect: Patients with Obesity and Thyroid Function Testing

According to a new guideline from the European Society of Endocrinology, patients with obesity should be routinely tested for thyroid function. However, testing for other endocrine-related conditions should be guided by the presence of symptoms. The endocrine system and obesity can have a push-pull relationship. Some endocrine disorders — such as hypothyroidism and Cushing’s syndrome...
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Eating a Late Dinner Linked to Weight Gain

Eating a late dinner may contribute to weight gain and high blood sugar, according to a small study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Over 2.1 billion adults are estimated to have overweight or obesity which make health complications like diabetes and high blood pressure more likely. Some studies suggest that consuming calories...
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People with Brown Fat May Burn 15 Percent More Calories

New data highlights how cold exposure activates brown fat, energy metabolism Short-term cold exposure may help people with brown fat burn 15 percent more calories than those without, according to a small study published in The Journal of Clinical Endocrinology & Metabolism. Unlike white fat, brown fat burns calories through fatty acid oxidation and heat production and is considered a promising target in the fight against the obesity epidemic. The biggest activator of brown fat is moderate cold exposure. “This data improves our understanding of how brown fat works...