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Most Frequent Pathogenic Mutation in RET Carries Very Low Lifetime Risk of Medullary Thyroid Cancer

The most frequent pathogenic mutation in the rearranged during transfection (RET) mutation — p.Val804Met – carries with it a very low lifetime risk of medullary thyroid cancer (MTC), which could mean the American Thyroid Association’s (ATA) recommendation of prophylactic thyroidectomy as standard for all RET mutation carriers is inappropriate, according to a study recently published...
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Persistent Organic Pollutants May Affect Child Growth and Development through Placental Thyroid Hormones

Exposure to persistent organic pollutants (POPs) is associated with thyroid hormone (TH) levels in placenta, which could explain how exposure to these chemicals affects child growth and development, according to a study recently published in Endocrinology. Researchers led by Zhong-Min Li, MSc, and Meri De Angelis, PhD, both of Helmholtz Zentrum München-German Research Center for...
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Thyroid Dysfunction May Lead to Diabetes during Pregnancy

Research supports thyroid screenings during early to mid-pregnancy Women with thyroid dysfunction in the first half of pregnancy face an increased risk for gestational diabetes, a form of diabetes that is typically diagnosed during the second trimester, according to a new study published in The Journal of Clinical Endocrinology & Metabolism. Thyroid dysfunction is common...
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Male Thyroid Cancer Survivors Face 50 Percent Higher Risk of Heart Disease than Women

Obesity also raises cardiovascular risk among thyroid cancer survivors Male thyroid cancer survivors have a nearly 50 percent higher risk of developing heart disease than women within five years of cancer diagnosis, according to a new study published in The Journal of Clinical Endocrinology & Metabolism. Thyroid cancer occurs when cancerous tumors or nodules grow...
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Test Significantly Reduces Unnecessary Surgeries in Thyroid Cancer Diagnoses

A RNA sequencing-based test significantly reduces the number of unnecessary surgeries in thyroid cancer diagnoses, according to a study recently published in JAMA Surgery. The test, marketed by Veracyte as their the next-generation Afirma Genomic Sequencing Classifier (GSC) identifies at least one third more benign thyroid nodules among those deemed indeterminate by cytopathology, as compared to...
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Decisions, Decisions: Controversies in Low-Risk DTC

decisions A study in a recent issue of Endocrine Reviews addresses the myriad controversies surrounding the treatment of low-risk differentiated thyroid cancer. While every facet of patient care has its own debates, education and more in-depth studies are key to finding common ground. Last August, a paper appeared in Endocrine Reviews aiming to address the controversies...

Endocrine News provides the latest news and research articles on thyroid conditions and treatment. For more info read this month’s issue of Endocrine News.