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Higher Prevalence of Evening Chronotype in Women with PCOS Associated with Worse Metabolic Profile

A higher prevalence of the evening chronotype in women with polycystic ovary syndrome (PCOS) is associated with a worse hormonal and metabolic profile, according to a paper recently published in the Journal of Pineal Research. Researchers led by Giovanna Muscogiuri, MD, PhD, an assistant professor in the Unit of Endocrinology at Federico II University Medical...
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Mouse Model of Transgender Men Finds Active Testosterone Worsens IVF Outcomes

A study presented at ENDO 2022 in Atlanta this past summer suggests that active testosterone therapy for transgender men may negatively impact IVF outcomes. Research presented by Amanda Schwartz, MD, a reproductive endocrinology and infertility fellow at the University of Michigan, found that female mice currently receiving testosterone had fewer and less developed eggs retrieved....
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New Study Makes Case for Culturing Embryos Up to Seven Days Post-Insemination for Selected Patients

Ending embryo culture at 144 hours (six days) post-insemination (h.p.i.) would involve 7.3 percent and 4.4 percent relative reductions in the number of patients obtaining euploid blastocysts and live birth(s) (LBs), respectively, according to a study published in Human Reproduction. The study results were announced recently by Fairtility, a company using artificial intelligence to enhance in...
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Stem Cells Show Promise in Treating Late-Onset Hypogonadism

Directed differentiation of human induced pluripotent (hiPSCs) into Leydig-like cells may be a novel and promising treatment for late-onset hypogonadism (LOH), according to a study recently published in Endocrinology. Researchers led by Takashi Aoi, MD, PhD, of Kobe University in Japan, point out that LOH is characterized by various symptoms, including erectile dysfunction, decreased muscle...