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Mouse Model of Transgender Men Finds Active Testosterone Worsens IVF Outcomes

A study presented at ENDO 2022 in Atlanta this past summer suggests that active testosterone therapy for transgender men may negatively impact IVF outcomes. Research presented by Amanda Schwartz, MD, a reproductive endocrinology and infertility fellow at the University of Michigan, found that female mice currently receiving testosterone had fewer and less developed eggs retrieved....
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New Study Makes Case for Culturing Embryos Up to Seven Days Post-Insemination for Selected Patients

Ending embryo culture at 144 hours (six days) post-insemination (h.p.i.) would involve 7.3 percent and 4.4 percent relative reductions in the number of patients obtaining euploid blastocysts and live birth(s) (LBs), respectively, according to a study published in Human Reproduction. The study results were announced recently by Fairtility, a company using artificial intelligence to enhance in...
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Stem Cells Show Promise in Treating Late-Onset Hypogonadism

Directed differentiation of human induced pluripotent (hiPSCs) into Leydig-like cells may be a novel and promising treatment for late-onset hypogonadism (LOH), according to a study recently published in Endocrinology. Researchers led by Takashi Aoi, MD, PhD, of Kobe University in Japan, point out that LOH is characterized by various symptoms, including erectile dysfunction, decreased muscle...
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Review Examines Relationship Between Gestational Diabetes and Offspring Fertility

A review recently published in Endocrinology offers some new insights on how maternal obesity-associated gestational diabetes (GDM) affects the reproductive health of offspring, discussing possible mechanisms, the latest perceptions, and highlighting areas that need further investigation. The review, by Niharika Sinha, PhD; Gretchen Lydia Walker; and Aritro Sen, PhD, all of Michigan State University in...
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COVID-19 Pandemic Associated with Disruptions to Women’s Reproductive Health

Women’s reproductive health has been disrupted as a result of the psychological burden of the COVID-19 pandemic, and affected women need additional medical and psychological support, according to research presented at the Society for Endocrinology annual conference in Edinburgh last November. The findings indicate that stress and sleep disturbance related to the pandemic have had...
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Stress From Rising Population Numbers May Cause a Decline in Human Fertility

A predicted population drop at the end of the century could be explained by stress from meaningless social interactions, according to a review article published in the Endocrine Society’s journal, Endocrinology. Researchers predict a peak in population numbers in 2064 followed by a 50% drop by the end of the century from changes in human reproductive behavior and function. There has been a 50% decrease in...