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Researchers Detail Snapshot of Proteins That Cause Type 2 Diabetes

Lipid nanodiscs stabilize misfolding protein intermediates red-handed When proteins misfold, accumulate, and clump in insulin-producing cells in the pancreas, they can kill these cells. Now, researchers at the Technical University of Munich (TUM), the University of Michigan, and the Helmholtz-Zentrum Muenchen have obtained a structural snapshot of these proteins when they are most toxic, detailing...
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2017: A Progress Report

progress report pic As endocrine science continues to be at the forefront of medical research, a wide array of treatment options, therapies, and products has been discovered. For the second year in a row, Endocrine News has compiled 2017’s newest items to treat a variety of endocrine disorders. As the Endocrine Society wrapped up its first century in...
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Eureka! Top Endocrine Discoveries of 2017

1217_Eureka! For the third year running, Endocrine News talks to editors from the Endocrine Society’s peer-reviewed journals to get the scoop on the top endocrine discoveries of 2017. Scientists know all too well that good research takes time. Breakthroughs are hard won, often requiring decades to achieve. Therefore, when notable progress does happen, it deserves to...
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Volanesorsen Shown to Reduce Triglyceride Levels in Patients with Severe Hypertriglyceridemia

Last month, our team presented data showing apolipoprotein C-III (apoC-III) inhibition with a RNA-targeted antisense therapy called volanesorsen effectively lowered triglycerides in patients with hypertriglyceridemia by 70%. This data was presented today at the National Lipid Association annual meeting in Philadelphia. Volanesorsen is designed to reduce the production of apoC-III, a protein produced in the...
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Cabergoline Tapering Successful at Maintaining Normal Prolactin Levels in Patients with Macroprolactinomas

Tapering cabergoline (CAB) levels can still maintain normal prolactin (PRL) levels in patients with macroprolactinomas, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Phillipe Chanson, MD, of Hopital de Bicetre in Le Kremlin-Bicetre, France, point out that CAB is “currently the dopamine agonist (DA) of choice” in...
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Low Body Mass Index Not Associated with Alzheimer’s Disease

Low body mass index is not associated with an increased risk of Alzheimer’s disease after all, according to a recent study published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Ruth Frikke-Schmidt, MD, DMSc, PhD, chief physician at Rigshospitalet in Copenhagen, Denmark, and associate research professor at the University of Copenhagen, point...