ATP-binding cassette (ABC) transporters are the major determinants of anaplastic thyroid cancer (ATC) resistance to chemotherapy, and these transporters could be key in tailoring treatments for patients with ATC, according to a paper recently published in Endocrinology. Researchers led by Vahid Haghpanah, MD, MPH, PhD, of the Endocrinology and Metabolism Research at the Tehran University...
Review Details Long-Term Cancer Treatment’s Effects on Endocrine System
Endocrine disorders are common in people who received cancer treatment in childhood and adulthood, especially as life expectancy in these patients continues to rise with the advance of these treatments, according to a paper recently published in Endocrine Reviews. The review, by Judith Gebauer, of the University Hospital of Schleswig-Holstein in Luebeck, Germany, points out...
Vascular Endothelial Growth Factor May Prevent Defective Uterine Artery Remodeling
Vascular endothelial growth factor (VEGF) delivery selectively to the placental basal plate (PBM) may prevent maternal and neonatal impairments caused by defective uterine artery remodeling (UAR), according to a primate study recently accepted for publication in Endocrinology. Researchers led by Eugene Albrecht, PhD, a professor of medicine in the Department of Obstetrics, Gynecology, and Reproductive...
Case Study Illuminates Adrenocortical Carcinoma’s Association with Lynch Syndrome
Adrenocortical carcinoma (ACC) can be the only manifestation in patients with Lynch syndrome – which is already associated with a higher risk of colorectal cancer and endometrial cancer – according to a paper recently published in the Journal of the Endocrine Society. Researchers led by Irina Bancos, MD, of the Mayo Clinic in Rochester, Minn., point...
Researchers Find Evidence of Novel Pathway in Regulation of Body Weight, Temperature
Leptin receptor signaling in single-minded homolog gene (Sim1) neurons plays a role in the regulation of body weight and temperature, according to a mouse study recently published in Endocrinology. Researchers led by Masoud Ghamari-Langroudi, MD, PhD, of the Vanderbilt School of Medicine in Nashville, Tenn., point out that the obesity epidemic continues to grow, and...
Individuals who take statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis published in the British Journal of Clinical Pharmacology. Researchers led by Prof. Bruno Stricker, of the Erasmus Medical Centre, in the Netherlands point out that while there are several epidemiological...
Genetic Studies Provide Possible Mechanistic Link Between Endometriosis and Ovarian Cancer
Genetic breakthroughs from three recent whole-exome sequencing studies of endometrial and endometriotic epithelial cells provided some unexpected findings linking endometriosis and ovarian cancer, according to a paper recently published in Endocrinology. The paper, by Serdar E. Bulun, MD, of the Feinberg School of Medicine at Northwestern University in Chicago, notes that while associations between endometriosis...
Review Examines Relationship Between Atypical Femur Fractures and Bisphosphonates
A paper recently published in Endocrine Reviews covers atypical femur fractures (AFFs) and examines their relationship with bisphosphonates (BPs), as well as prevention and treatment of these rare but devastating bone breaks. The review, by Dennis M. Black, PhD, of the University of California, San Francisco, et al, points out that BPs have been the...
