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Postmenopausal women have increased risk of non-alcoholic fatty liver disease due to loss of estrogen from metabolic changes. A high-fat diet further exacerbates the disease, which can progress to cirrhosis and liver failure. Hormone replacement therapy (HRT) is an effective treatment, but it carries increased risk of breast cancer, uterine cancers, and cardiovascular disease. Researchers...
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A high-fat diet disturbs the body clock in rat brains that normally controls satiety, leading to over-eating and obesity, according to new research published in The Journal of Physiology. This new research may be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid...
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At the end of September, a paper appeared in the New England Journal of Medicine that showed omitting race from equations for estimated glomerular filtration rate (eGFR) leads to more accurate results when determining kidney function. The researchers, led by Lesley Inker, MD, MS, director of the Kidney Function and Evaluation Center at Tufts Medical...
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A new analysis from the STAMPEDE trial shows that over the course of five years, patients who had bariatric and metabolic surgery to treat uncontrolled type 2 diabetes reported greater physical health, more energy, less body pain, and less negative effects of diabetes in their daily lives, compared with patients who had medical therapy alone...
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HIV-1, the most common type of human immunodeficiency virus, invades the testis and is able to avoid combination antiretroviral (cART) drugs by permeating the blood-testis barrier (BTB) and perturbing BTB function, potentially through the Tat protein, according to a study recently published in Endocrinology. Researchers led by C. Yan Cheng, PhD, senior scientist at The...
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Radiographic arthropathy progresses significantly in patients with long-term, well-controlled acromegaly, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Iris C. M. Pelsma, MD, MSc, of Leiden University Medical Center in The Netherlands, point out that one of the long-term complications of acromegaly is acromegalic arthropathy, which...
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Tumor size and random growth hormone concentration at diagnosis are the best predictors for remission of acromegaly after transsphenoidal surgery (TSS), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Eva C. Coopmans, MD, of Erasmus University Medical Center in Rotterdam, The Netherlands, point out that TSS...
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Machine learning (ML), a type of artificial intelligence, could be used to predict how patients with acromegaly respond to first-generation somatostatin receptor ligands (fg-SRLs), according a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Mônica Gadelha, MD, PhD, of the Endocrine Unit and Neuroendocrinology Research Center at the Medical...
