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Pancreatic Cancer ‘Time Machine’ Reveals Heterogeneous Nature of the Disease

A pancreatic cancer “time machine” has revealed that the disease is even more unpredictable than previously thought: Cancer cells promote each other’s invasiveness when they grow together, according to a paper recently published in Small. Researchers led by Stephen Konieczny, PhD, professor of biological sciences at Purdue University, and Bumsoo Han, PhD, professor of biomedical...
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Testosterone Supplementation in Healthy Men with Severe Short-Term Energy Deficit Prevents Increase in Circulating Ghrelin without Suppressing Appetite

Testosterone supplementation prevents an increase in circulating ghrelin but does not appear to affect appetite or energy intake in healthy men who are suffering from a severe, short-term energy deficit, according to a study recently published in the Journal of the Endocrine Society. Researchers led by J. Philip Karl, PhD, RD, and Stefan M. Pasiakos,...
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BPA Exposure Leads to Abnormal Estrous Cycle and Folliculogenesis, Mouse Study Finds

Exposure to bisphenol A (BPA), even at environmentally low doses, disrupts the preovulatory luteinizing hormone (LH) surge and leads to abnormal estrous cycle and folliculogenesis, according to a study recently published in Endocrinology. This disruption is reversible following adult exposure, but it persists into adulthood after neonatal exposure. Researchers led by David Lopez-Rodriguez, MSc, at the neuroendocrinology...
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Review Examines Optimal Care for Patients with 46,XY Differences of Sex Development

Treating patients with 46,XY differences of sex development (DSD) will require interdisciplinary healthcare teams trained to care for patients and their families, according to a paper recently published in Endocrine Reviews. The review, by Amy B. Wisniewski, of Oklahoma State University in Stillwater, et al., points out that DSD are a heterogenous group of congenital...
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Slightly Elevated TSH Levels Not a Cause for Referral to Pediatric Endocrinologists

Children with thyroid stimulating hormone (TSH) levels slightly above reference range shouldn’t be referred to pediatric endocrinologists unless there is another cause for clinical concern, according to a paper recently published in the Journal of the Endocrine Society. Researchers led by Perrin C. White, MD, of the Division of Pediatric Endocrinology at the University of...
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E-cigarette Use during Pregnancy Impairs Metabolic Health in Daughters, Mouse Study Finds

E-cigarette usage may impair fertility and pregnancy outcomes, according to a mouse study published in the Journal of the Endocrine Society. Researchers led by Kathleen Caron, PhD, of University of North Carolina at Chapel Hill, N.C., point out that while the dangers of cigarette smoke are well established, the England Public Health system has ruled e-cigarettes...
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Case Study Illuminates Metreleptin’s Possible Role in Improving Lipid and Glycemic Profiles

Researchers in Japan have detailed a case report in which a young woman who survived childhood cancer was treated with metreleptin supplementation to improve her acquired incomplete lipodystrophy and published their findings in the Journal of the Endocrine Society. The researchers, led by Ayako Nagayama, MD, and Kenji Ashida, MD, PhD, (Nomura Laboratory) of Kurume...
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Protein Kinase Revealed to Regulate Body Weight and Energy Homeostasis

Researchers have identified a protein kinase that controls weight and homeostasis and when deficient or inactivated can lead to metabolic diseases like obesity and type 2 diabetes, according to a mouse study recently published in Endocrinology. Researchers led by Eiichi Hinoi of the Laboratory of Pharmacology in the Department of Bioactive Molecules at Gifu Pharmaceutical...