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Genetic Studies Provide Possible Mechanistic Link Between Endometriosis and Ovarian Cancer

Genetic breakthroughs from three recent whole-exome sequencing studies of endometrial and endometriotic epithelial cells provided some unexpected findings linking endometriosis and ovarian cancer, according to a paper recently published in Endocrinology. The paper, by Serdar E. Bulun, MD, of the Feinberg School of Medicine at Northwestern University in Chicago, notes that while associations between endometriosis...
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Researchers Reveal Novel Mechanism in Luminal Breast Cancer Development

Researchers have identified unique isoform-specific functions of phosphorylated progesterone receptors (PRs) as pathway drivers in the development of luminal breast cancer, according to a study recently published in Endocrinology. Researchers led by Carol A. Lange, PhD, of the Masonic Cancer Center at the University of Minnesota in Minneapolis, point out that luminal, or estrogen receptor...
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Childhood Exposure to Passive Smoking Linked to Impaired Bone Health in Adulthood

Children of parents who smoke have evidence of impaired bone health in adulthood, according to a study recently published in The Journal of Clinical Endocrinology and Metabolism. Researchers led by Markus Juonala, MD, PhD, of the University of Turku and Division of Medicine, Turku University Hospital, and FinlandMurdoch Childrens Research Institute in Parkville, Victoria, Australia,...
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Most Frequent Pathogenic Mutation in RET Carries Very Low Lifetime Risk of Medullary Thyroid Cancer

The most frequent pathogenic mutation in the rearranged during transfection (RET) mutation — p.Val804Met – carries with it a very low lifetime risk of medullary thyroid cancer (MTC), which could mean the American Thyroid Association’s (ATA) recommendation of prophylactic thyroidectomy as standard for all RET mutation carriers is inappropriate, according to a study recently published...
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Biomarker Risk Score May Identify Women at Risk for Gestational Diabetes

The predictive ability of a biomarker risk score beyond established risk factors may help identify women at risk of developing gestational diabetes (GDM) before conception and help with tailoring targeted prevention strategies, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Sylvia E. Badon, PhD, of the Division...