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Progression of Acromegalic Arthropathy Observed in Long-Term Study

Radiographic arthropathy progresses significantly in patients with long-term, well-controlled acromegaly, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Iris C. M. Pelsma, MD, MSc, of Leiden University Medical Center in The Netherlands, point out that one of the long-term complications of acromegaly is acromegalic arthropathy, which...
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Researchers Determine Best Predictors of Acromegaly Remission Following Transsphenoidal Surgery

Tumor size and random growth hormone concentration at diagnosis are the best predictors for remission of acromegaly after transsphenoidal surgery (TSS), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Eva C. Coopmans, MD, of Erasmus University Medical Center in Rotterdam, The Netherlands, point out that TSS...
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Researchers Develop Machine-Learning Prediction Model to Improve Medical Management of Acromegaly

Machine learning (ML), a type of artificial intelligence, could be used to predict how patients with acromegaly respond to first-generation somatostatin receptor ligands (fg-SRLs), according a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Mônica Gadelha, MD, PhD, of the Endocrine Unit and Neuroendocrinology Research Center at the Medical...
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New App Helps Improve Diabetes Care in Patients with COVID-19

Last month, Endocrine News ran a feature about the need optimal glycemic control in patients hospitalized with COVID-19, which could require physicians treating these patients to take different approaches than usual. Now, an international group of healthcare experts have developed an app to help the providers on the front lines of caring for patients with...
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Consuming Sucralose with Carbohydrates May Impair Insulin Sensitivity, Study Finds

Consuming sucralose-sweetened beverages with carbohydrates may impair insulin sensitivity, according to a study recently published in Cell Metabolism. Researchers led by Dana M. Small, PhD, director of the Modern Diet and Physiology Research Center at Yale University in New Haven, Conn., point out that there is still significant controversy surrounding the effects of no- or...
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Pancreatic Cancer ‘Time Machine’ Reveals Heterogeneous Nature of the Disease

A pancreatic cancer “time machine” has revealed that the disease is even more unpredictable than previously thought: Cancer cells promote each other’s invasiveness when they grow together, according to a paper recently published in Small. Researchers led by Stephen Konieczny, PhD, professor of biological sciences at Purdue University, and Bumsoo Han, PhD, professor of biomedical...
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Testosterone Supplementation in Healthy Men with Severe Short-Term Energy Deficit Prevents Increase in Circulating Ghrelin without Suppressing Appetite

Testosterone supplementation prevents an increase in circulating ghrelin but does not appear to affect appetite or energy intake in healthy men who are suffering from a severe, short-term energy deficit, according to a study recently published in the Journal of the Endocrine Society. Researchers led by J. Philip Karl, PhD, RD, and Stefan M. Pasiakos,...
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BPA Exposure Leads to Abnormal Estrous Cycle and Folliculogenesis, Mouse Study Finds

Exposure to bisphenol A (BPA), even at environmentally low doses, disrupts the preovulatory luteinizing hormone (LH) surge and leads to abnormal estrous cycle and folliculogenesis, according to a study recently published in Endocrinology. This disruption is reversible following adult exposure, but it persists into adulthood after neonatal exposure. Researchers led by David Lopez-Rodriguez, MSc, at the neuroendocrinology...
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