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Genetic breakthroughs from three recent whole-exome sequencing studies of endometrial and endometriotic epithelial cells provided some unexpected findings linking endometriosis and ovarian cancer, according to a paper recently published in Endocrinology. The paper, by Serdar E. Bulun, MD, of the Feinberg School of Medicine at Northwestern University in Chicago, notes that while associations between endometriosis...
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A paper recently published in Endocrine Reviews covers atypical femur fractures (AFFs) and examines their relationship with bisphosphonates (BPs), as well as prevention and treatment of these rare but devastating bone breaks. The review, by Dennis M. Black, PhD, of the University of California, San Francisco, et al, points out that BPs have been the...
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Researchers have identified unique isoform-specific functions of phosphorylated progesterone receptors (PRs) as pathway drivers in the development of luminal breast cancer, according to a study recently published in Endocrinology. Researchers led by Carol A. Lange, PhD, of the Masonic Cancer Center at the University of Minnesota in Minneapolis, point out that luminal, or estrogen receptor...
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A paper recently published in Endocrine Reviews concludes that primary hypertension is not a disease but rather a syndrome, and that genetics may hold the key to targeted and individualized treatment. The review, by Worapaka Manosroi, MD, and Gordon H. Williams, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, points out...
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Children of parents who smoke have evidence of impaired bone health in adulthood, according to a study recently published in The Journal of Clinical Endocrinology and Metabolism. Researchers led by Markus Juonala, MD, PhD, of the University of Turku and Division of Medicine, Turku University Hospital, and FinlandMurdoch Childrens Research Institute in Parkville, Victoria, Australia,...
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Children born in the most recent century have bones that reach full maturity earlier – by nearly 10 months in girls and nearly seven months in boys, according to a study recently published in Clinical Orthopaedics and Related Research. Researchers led by Dana Duren, PhD, director of orthopaedic research at the Thompson Laboratory for Regenerative Orthopaedics...
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The most frequent pathogenic mutation in the rearranged during transfection (RET) mutation — p.Val804Met – carries with it a very low lifetime risk of medullary thyroid cancer (MTC), which could mean the American Thyroid Association’s (ATA) recommendation of prophylactic thyroidectomy as standard for all RET mutation carriers is inappropriate, according to a study recently published...
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The predictive ability of a biomarker risk score beyond established risk factors may help identify women at risk of developing gestational diabetes (GDM) before conception and help with tailoring targeted prevention strategies, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Sylvia E. Badon, PhD, of the Division...
