Beta-arrestins attach themselves to outer cell membranes, waiting for hormones or neurotransmitters to land on receptors – an unexpected and surprising finding recently published in Cell. Researchers led by Davide Calebiro, MD, professor of Molecular Endocrinology in the Institute of Metabolism and Systems Research at the University of Birmingham and Co-Director of the Centre of...
Mouse Study Hints at Specific Brain Receptor behind PCOS Symptoms
Deletion of androgen receptors (ARs) in leptin receptor (LepRb) neurons improves estrous cycles, providing a possible therapeutic target for the symptoms of polycystic ovarian syndrome (PCOS), according to a mouse study recently published in Endocrinology. Researchers led by Carol F. Elias, PhD, of the University of Michigan Medical School’s Department of Molecular and Integrative Physiology,...
Tirzepatide Safe and Tolerable in Treatment of Type 2 Diabetes, Researchers Find
Tirzepatide – the dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) injection used to treat type 2 diabetes – is safe and has a tolerable adverse event (AE) profile in its role in the management of T2D, and possibly obesity, according to a study recently published in the Journal of the... Weight loss achieved through the use of a combination of anti-obesity medications (AOMs) can approach the reduction seen in bariatric surgery, according to a paper recently published in JCEM Case Reports. Researchers led by Priya N. Patel, MD, of the Center for Pediatric Obesity Medicine at the University of Minnesota Medical School in Minneapolis point...
Mutations of the Fragile X messenger ribonucleoprotein 1 gene (Fmr1) — a leading genetic cause of intellectual impairment and autism — contribute to premature ovarian failure (POF) due to changes in neurons that regulate reproduction in the brain and ovaries, according to a study recently published in Frontiers in Endocrinology. Researchers led by Djurdjica Coss,...
Demand for testosterone therapy has soared in the United States with more men seeking to increase hormone levels in hopes of enhancing virility, strength and energy. Testosterone therapy has become a burgeoning business with direct-to-consumer men’s health platforms proliferating online in recent years. While testosterone therapy benefits some men, it can be harmful for others,...
One type of bacteria found in the gut may contribute to the development of type 2 diabetes, while another may protect from the disease, according to early results from an ongoing, prospective study recently published in Diabetes. Researchers led by Mark Goodarzi, MD, PhD, director of the Endocrine Genetics Laboratory at Cedars-Sinai Medical Center...
Study Reveals Obesity-Related Trigger that Can Lead to Diabetes
People with elevated levels of insulin also have defects in an enzyme important to the processing of a key fatty acid from the diet, according to research recently published in Cell Metabolism. The study may help explain how excess weight can contribute to diabetes and may provide researchers with a target to help prevent or...
