The U.S. Food and Drug Administration (FDA) last month approved leuprolide acetate for injectable suspension for the treatment of pediatric patients two years of age and older with central precocious puberty (CPP). Tolmar Pharmaceuticals is marketing the drug as Fensolvi. Leuprolide acetate is the most widely used treatment for CPP. Fensolvi utilizes a proprietary polymeric gel...
Review Examines Genome-Wide Association Studies’ Effects on Understanding of Human Growth
A review recently published in The Journal of Clinical Endocrinology & Metabolism looks at how genome-wide association studies (GWASs) have impacted the medical community’s understanding of the underlying biology of human growth. The paper, by Michael H. Guo, of the Broad Institute of MIT and Harvard in Cambridge, Mass., et al., summarizes key findings of...
A French study published in the Journal of the Endocrine Society reveals myriad complications that many acromegaly patients face after they’ve been successfully treated. Lead researcher Frederic Castinetti, MD, PhD, discusses his research and why follow-up may still be required once a patient is “cured.” Last December, a paper appeared in the Journal of the Endocrine Society...Researchers Find Slightly Elevated Cancer Incidence in Patients with Acromegaly
Cancer incidence rates are slightly elevated in patients with acromegaly, according to a meta-analysis recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Jens Otto Lunde Jørgensen, MD, DMSc, of the Department of Endocrinology and Internal Medicine at Aarhus University Hospital in Norrebrogade, Denmark point out that acromegaly has been associated...
A paper published recently in the Journal of the Endocrine Society details a case of a woman with acromegaly-like features, but she did not have excess growth hormone (GH) secretion. The authors use the case to show that differential diagnoses should be considered in these patients with “pseudoacromegaly” or “acromegaloidism.” The paper, by Per Dahlqvist,...
This issue highlights Pediatric Endocrine Self-Assessment Program. Test your clinical knowledge and prepare for your exam. Available on the online store. Clinical Vignette A 6-and-a-half-year-old boy presents for evaluation of short stature. He was growing along the 5th percentile until age 4 years. His birth history is unremarkable. His parents are of low-normal stature... Disrupting the growth hormone receptor (Ghr) gene in adult mice increased the maximal lifespan in the female mice, but not the males, according to a study recently published in Endocrinology. Researchers led by John J. Kopchick, PhD, of the Edison Biotechnology Institute and Ohio University in Athens, write that many animals have shown increased lifespans...
Ever since a French study linked growth hormone therapy to strokes two years ago, the debate has raged on in the endocrinology community. While most agree that more studies are needed, researchers disagree on how to proceed. Two years ago, shockwaves shook the endocrinology science community when a study purported a link between growth hormone...
