Last month, our team presented data showing apolipoprotein C-III (apoC-III) inhibition with a RNA-targeted antisense therapy called volanesorsen effectively lowered triglycerides in patients with hypertriglyceridemia by 70%. This data was presented today at the National Lipid Association annual meeting in Philadelphia. Volanesorsen is designed to reduce the production of apoC-III, a protein produced in the...
Tapering cabergoline (CAB) levels can still maintain normal prolactin (PRL) levels in patients with macroprolactinomas, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Phillipe Chanson, MD, of Hopital de Bicetre in Le Kremlin-Bicetre, France, point out that CAB is “currently the dopamine agonist (DA) of choice” in...
Low body mass index is not associated with an increased risk of Alzheimer’s disease after all, according to a recent study published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Ruth Frikke-Schmidt, MD, DMSc, PhD, chief physician at Rigshospitalet in Copenhagen, Denmark, and associate research professor at the University of Copenhagen, point...
Disrupting the growth hormone receptor (Ghr) gene in adult mice increased the maximal lifespan in the female mice, but not the males, according to a study recently published in Endocrinology. Researchers led by John J. Kopchick, PhD, of the Edison Biotechnology Institute and Ohio University in Athens, write that many animals have shown increased lifespans...
Endocrine science has been at the forefront of research and treatment of a variety of endocrine disorders. The result is a wide array of therapies, products, and more that came to market in 2016, which Endocrine News has compiled here. This past year was the 100th year of the Endocrine Society and it was not...
A new website called TrialsLoop.com that provides user-generated reviews for clinical trials as well as easy access to participate in clinical trials has recently launched. Management expects to gradually get patients in clinical trials to rate their experience, share it with others who might be considering entering a similar clinical trial and form a community...
Endocrine-disrupting chemicals linked to altered hormone levels, ovarian development in mice. Prenatal exposure to chemicals used in hydraulic fracturing, or fracking, may threaten fertility in female mice, according to a new study published in the Endocrine Society’s journal Endocrinology. The study was the first to find a link between chemical exposure and adverse reproductive and developmental...
Tributyltin chloride (TBT) – a chemical used in antifouling paints, and a known endocrine-disrupting chemical (EDC) – disrupts the hypothalamus-pituitary-adrenal (HPA) axis in female rats, according to a study recently published in Endocrinology. Researchers led by Professor Jones B. Graceli, of Universidade Federal do Espírito Santo, in Vitória, ES, Brazil, point out that TBT has...
Endocrine science has been at the forefront of research and treatment of a variety of endocrine disorders. The result is a wide array of therapies, products, and more that came to market in 2016, which Endocrine News has compiled here. This past year was the 100th year of the Endocrine Society and it was not...
