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First Clinical Trial of Vosoritide for Children with Hypochondroplasia Shows Increased Growth

The first global phase 2 study of vosoritide showed an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a genetic cause of short stature in children, according to a paper recently published in eClinicalMedicine. The clinical trial is funded by BioMarin. Researchers led by Andrew Dauber, MD, chief of Endocrinology at Children’s...
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A Relentless Pursuit: JES Invites Collaborative Obesity Research

jes_8_6cover Three editors of the Journal of the Endocrine Society (JES) recently published an editorial titled “From Fundamentals to the Clinic: Advancing Obesity Research in Endocrinology,” recognizing that the landscape of obesity research has rapidly evolved in the past five years, and that sharing scientific data is an important step toward addressing the growing global obesity...
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Investigators Describe Changes to Pancreatic Beta-Cell at Onset of Type 1 Diabetes

New research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of type 1 diabetes. Their findings—published in Nature Cell Biology—offer new avenues for targeted interventions for the chronic autoimmune condition.  “In the field of type 1 diabetes, research has largely focused on understanding the immune...
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Incarceration Nation: Administering Endocrine Healthcare in Our Nation’s Prisons

A first-of-its-kind session at ENDO 2024 will discuss healthcare management for the most underserved of the underserved: the incarcerated. The session, “Endocrine Care for Incarcerated Individuals,” will offer a detailed look at not only what it’s like to be incarcerated, but also the challenges of delivering appropriate endocrine treatment to this often unfairly stigmatized population....
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High Fat Diet Influences Milk Lipids in Lactating Women

Maternal exposure to a high fat diet (HFD) alters milk lipids in lactating women, enhancing adiposity and myeloid inflammation in offspring, even in early life, according to an animal study recently published in Endocrinology. Researchers led by Kanakadurga Singer, MD, and Brigid Gregg, MD, both of the University of Michigan in Ann Arbor, point out...
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Bad Reception: Unlocking a Confounding Enigma Behind Monogenic Obesity in Children

When two very different pediatric patients with obesity presented with unusually high leptin levels, endocrine researchers took notice and discovered that leptin was not adequately binding with receptors. When the young patients’ familial history was considered, solutions were finally forthcoming. About three years ago, a 19-month-old girl presented to Sidra Medicine – a women’s and...