Maternal exposure to a high fat diet (HFD) alters milk lipids in lactating women, enhancing adiposity and myeloid inflammation in offspring, even in early life, according to an animal study recently published in Endocrinology. Researchers led by Kanakadurga Singer, MD, and Brigid Gregg, MD, both of the University of Michigan in Ann Arbor, point out...
Author: Derek Bagley
Bad Reception: Unlocking a Confounding Enigma Behind Monogenic Obesity in Children
When two very different pediatric patients with obesity presented with unusually high leptin levels, endocrine researchers took notice and discovered that leptin was not adequately binding with receptors. When the young patients’ familial history was considered, solutions were finally forthcoming. About three years ago, a 19-month-old girl presented to Sidra Medicine – a women’s and...
Having a Ball: What Can Be Done About Pediatric Dyslipidemia?
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. Study author Andrew O. Agbaje, MD, MPH, FESC, talks to Endocrine News about the study’s findings, the arbitrary nature of some guidelines,... On the 20th anniversary of the U.S. Food and Drug Administration’s approval of growth hormone (GH) treatment for idiopathic short stature (ISS), Adda Grimberg, MD, and Colin P. Hawkes, MD, PhD, both of the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, published a mini-review in The Journal...
Childhood cancer patients and survivors are at increased risk for growth disturbances, for myriad reasons, and it is important to periodically monitor their growth, according to a paper recently published in The Journal of Clinical Endocrinology & Metabolism. Tomoko Yoshida, MD, PhD, and Angela Delaney, MD, both of St. Jude Children’s Research Hospital in Memphis,...
Liraglutide Increases Insulin Sensitivity Independent of Weight Loss, Study Shows
Liraglutide, the glucagon-like peptide-1 receptor (GLP-1R) agonist used to treat type 2 diabetes and obesity, can lead to rapid improvement in insulin sensitivity, according to a study recently published in Diabetes. “We know that GLP-1R agonists promote weight loss, but we were surprised to find that the GLP-1R agonist liraglutide also has rapid effects on...
The increase in free insulin-like growth factor (IGF)-I levels in prepubertal children with Prader-Willi Syndrome (PWS) treated with exogenous growth hormone (GH) could be caused by increased pregnancy-associated plasma protein A (PAPP-A, PAPP-A2) levels and a reduction in stanniocalcins (STC-1, STC-2), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism....
Word of Honour: John William Honour, PhD, FRCPATH, Discusses His Recent Book on Steroids
An Endocrine Society member since 1979, John William Honour, PhD, FRCPath, used his time in lockdown to write a voluminous tome on steroids. He talks to Endocrine News about his recent book, Steroids in the Laboratory and Clinical Practice, how it was impacted by the COVID-19 pandemic, and why it may just be the definitive...