New pooled data from Phase 2 and Phase 3 clinical trials further reinforce that teprotumumab-trbw significantly improves proptosis (eye bulging) and diplopia (double vision) for thyroid eye disease (TED) in patients in different subgroups, with most maintaining a long-term response. The results were published recently in The Lancet Diabetes & Endocrinology. Teprotumumab-trbw is a fully human...
Machine learning (ML), a type of artificial intelligence, could be used to predict how patients with acromegaly respond to first-generation somatostatin receptor ligands (fg-SRLs), according a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Mônica Gadelha, MD, PhD, of the Endocrine Unit and Neuroendocrinology Research Center at the Medical...
Long-term pegvisomant therapy for acromegaly can lead to a sustained increase in adiposity but no change in skeletal muscle mass, according to a study recently published in Journal of the Endocrine Society. Researchers led by Pamela U. Freda, MD, of the Columbia University Department of Medicine in New York, point out that pegvisomant, a growth...
When Robert J. Lefkowitz, MD, received the Nobel Prize for Chemistry in 2012, that was only part of his storied career as a physician scientist. With a new book on the shelves – and online shopping carts – Lefkowitz talks to Endocrine News about misconceptions about scientists, what inspired him to write a book, and...
There were no significant differences in health outcomes for pregnant women who were diagnosed with gestational diabetes or their babies using two different clinically recommended screening methods, according to results from a large-scale clinical trial conducted by Kaiser Permanente researchers and published in The New England Journal of Medicine. Although there is evidence that treating...
Data from a Phase 3 trial presented this week at ENDO2021 showed that octreotide capsules improved clinical symptoms and other patient-reported outcomes compared to long-acting injectable somatostatin receptor ligands (iSRLs) in patients with acromegaly. The data went on to show that 90% of patients receiving octreotide capsules elected to enroll in the open-label extension (OLE)...
A relatively new field, transgender medicine will be featured in the ENDO 2021 session, “Transgender Care: A Comprehensive Assessment for a Multi-Faceted Condition,” a live, 90-minute program taking place Sunday, March 21, 2021, at 12:15 p.m. Program co-chair, Stephen M. Rosenthal, MD, and Sabine Hannema, MD, PhD, talk to Endocrine News about what attendees can...
Factors other than how much weight a woman gains during pregnancy may contribute to metabolic complications such as gestational diabetes (GDM), according to a paper recently published in Journal of the Endocrine Society. Researchers led by Fernanda L. Alvarado, MD, of the Mother Infant Research Institute at Tufts Medical Center in Boston, Mass., point out...
When Robert J. Lefkowitz, MD, received the Nobel Prize for Chemistry in 2012, that was only part of his storied career as a physician scientist. With a new book on the shelves – and online shopping carts – Lefkowitz talks to Endocrine News about misconceptions about scientists, what inspired him to write a book, and...