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The immunosuppressant and anticancer agent everolimus has been shown to directly suppress insulin secretion in metastatic insulinoma, independently of the drug’s effect on tumor growth, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Takeshi Miyatsuka, MD, PhD, of the Department of Metabolism and Endocrinology, Juntendo University Graduate...
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[CLARIFICATION: The results of this study were based on a small sample of patients who continued insulin treatment, and further research is needed. A previous version of this article seemed to imply that the BCG vaccine alone restored normal blood sugar levels. That is not the case; we regret the error.] Long-term follow-up of participants...
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The HSD3B1 gene is positively regulated by androgens and androgen receptors (ARs), a finding that may play a role in more tailored treatment of prostate cancer, according to a study recently published in Endocrinology. Researchers led by Nima Sharifi, MD, of the Cleveland Clinic in Cleveland, Ohio, point out that prostate cancer requires gonadal testosterone...
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Cancer incidence rates are slightly elevated in patients with acromegaly, according to a meta-analysis recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Jens Otto Lunde Jørgensen, MD, DMSc, of the Department of Endocrinology and Internal Medicine at Aarhus University Hospital in Norrebrogade, Denmark point out that acromegaly has been associated...
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A paper recently published in Endocrine Reviews presents a comprehensive look at Klinefelter syndrome (KS), a rare disease that poses diagnostic challenges and remains largely misunderstood in the medical community. The review, by Claus H. Gravholt, MD, PhD, of the Department of Endocrinology and Internal Medicine (MEA) at Aarhus University Hospital in Norrebrogade, Denmark, et...
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South Asian immigrants exposed to higher levels of organochlorine (OC) pesticides also are at a higher risk of developing diabetes, meaning there could be a positive association between these pesticides and incidence of diabetes, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Martyn T. Smith, PhD, of...
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Metabolic syndrome (MetS) modifies the association between testosterone and mortality in older men, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Marianne Canonico, PhD, of the Université de Versailles St-Quentin-en-Yvelines, Center for Research in Epidemiology and Population Health, INSERM, in Versailles, France, point out that there have...
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Researchers may have come across a novel treatment target to treat the rare but aggressive cancer adrenocortical carcinoma (ACC), according to a study recently published in Endocrinology. The researchers, led by Wiebke Arlt and Paul A. Foster, both of the University of Birmingham in the United Kingdom, write that the mitochondrial NADPH generator Nicotinamide Nucleotide...
