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The most frequent pathogenic mutation in the rearranged during transfection (RET) mutation — p.Val804Met – carries with it a very low lifetime risk of medullary thyroid cancer (MTC), which could mean the American Thyroid Association’s (ATA) recommendation of prophylactic thyroidectomy as standard for all RET mutation carriers is inappropriate, according to a study recently published...
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The predictive ability of a biomarker risk score beyond established risk factors may help identify women at risk of developing gestational diabetes (GDM) before conception and help with tailoring targeted prevention strategies, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Sylvia E. Badon, PhD, of the Division...
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A recent animal model shows that the adrenal clock may help stabilize the circadian glucocorticoid rhythm in response to chronic exposure to aberrant light cycles, according to a study recently published in Endocrinology. Researchers led by William C. Engeland, PhD, of the Department of Neuroscience at the University of Minnesota in Minneapolis, point out that...
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Being overweight or obese is linked with an increased risk of developing urinary incontinence for young to middle-aged women, according to a review and meta-analysis recently published in Obesity Reviews. The authors wanted to evaluate whether overweight or obesity are risk factors for young and middle-aged women developing incontinence. “Understanding these relationships during this life stage...
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A review recently published in The Journal of Clinical Endocrinology & Metabolism looks at how genome-wide association studies (GWASs) have impacted the medical community’s understanding of the underlying biology of human growth. The paper, by Michael H. Guo, of the Broad Institute of MIT and Harvard in Cambridge, Mass., et al., summarizes key findings of...
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The U.S. Preventive Services Task Force (USPSTF) last month released a final recommendation statement and evidence summary on behavioral weight loss interventions to prevent obesity-related morbidity and mortality in adults. Based on its review of the evidence, the USPSTF recommends that clinicians offer or refer adults with a body mass index (BMI) of 30 kg/m2...
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A recent mouse study may provide a path to future cell-based therapies for leptin deficiency, according to a report published in Endocrinology. Researchers led by Charles A. Harris, MD, PhD, of Washington University School of Medicine in St. Louis, point out that metabolic syndrome is a global epidemic, and about 35% of U.S. adults meet...
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Type 1 diabetes research and clinical trials will continue to fail to meet their goals until several knowledge gaps are acknowledged and addressed, according to a paper recently published in The Journal of Clinical Endocrinology & Metabolism. The perspective article, by David Bleich, MD, of Rutgers New Jersey Medical School in Rutgers, N.J., and David...
