A paper recently published in Endocrine Reviews looks to provide readers with an improved understanding in approaches to using hormone therapy to treat menopausal women. The review, by Valerie Flores, MD, and Lubna Pal, MD, of Yale School of Medicine and JoAnn Manson, MD, of Harvard Medical School, points out that hormone therapy remains the...
Postmenopausal Women May Benefit from Estrogen Compound Research
Postmenopausal women have increased risk of non-alcoholic fatty liver disease due to loss of estrogen from metabolic changes. A high-fat diet further exacerbates the disease, which can progress to cirrhosis and liver failure. Hormone replacement therapy (HRT) is an effective treatment, but it carries increased risk of breast cancer, uterine cancers, and cardiovascular disease. Researchers...
High-Fat Diet Impairs Circadian Rhythms in Mice, Study Finds
A high-fat diet disturbs the body clock in rat brains that normally controls satiety, leading to over-eating and obesity, according to new research published in The Journal of Physiology. This new research may be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid...
Omitting Race from Kidney Function Equations Leads to More Accurate Results
At the end of September, a paper appeared in the New England Journal of Medicine that showed omitting race from equations for estimated glomerular filtration rate (eGFR) leads to more accurate results when determining kidney function. The researchers, led by Lesley Inker, MD, MS, director of the Kidney Function and Evaluation Center at Tufts Medical...
Patients Report Long-Term Favorable Effects of Weight Loss Surgery in Their Daily Lives
A new analysis from the STAMPEDE trial shows that over the course of five years, patients who had bariatric and metabolic surgery to treat uncontrolled type 2 diabetes reported greater physical health, more energy, less body pain, and less negative effects of diabetes in their daily lives, compared with patients who had medical therapy alone...
HIV-1 Establishes “Sanctuary Site” In the Testis by Disrupting Blood-Testis Barrier Function
HIV-1, the most common type of human immunodeficiency virus, invades the testis and is able to avoid combination antiretroviral (cART) drugs by permeating the blood-testis barrier (BTB) and perturbing BTB function, potentially through the Tat protein, according to a study recently published in Endocrinology. Researchers led by C. Yan Cheng, PhD, senior scientist at The...
Progression of Acromegalic Arthropathy Observed in Long-Term Study
Radiographic arthropathy progresses significantly in patients with long-term, well-controlled acromegaly, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Iris C. M. Pelsma, MD, MSc, of Leiden University Medical Center in The Netherlands, point out that one of the long-term complications of acromegaly is acromegalic arthropathy, which...
Researchers Determine Best Predictors of Acromegaly Remission Following Transsphenoidal Surgery
Tumor size and random growth hormone concentration at diagnosis are the best predictors for remission of acromegaly after transsphenoidal surgery (TSS), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Eva C. Coopmans, MD, of Erasmus University Medical Center in Rotterdam, The Netherlands, point out that TSS...
