The testosterone replacement therapy (TRT) testosterone undecanoate oral capsules shows no evidence of liver toxicity, according to data from a two-year, multi-center study presented at ENDO 2021. Marketed under the brand name JATENZO® by Clarus Therapeutics, Inc., this oral softgel has been commercially available since February 2020 after a March 2019 approval by the U.S....
Illegal use of anabolic steroids not only has dangerous side effects during use but also can harm men’s testicular function years after they stop abusing steroids, according to a study published in The Journal of Clinical Endocrinology & Metabolism. Anabolic steroids are synthetic forms of testosterone, and their abuse is prevalent among athletes worldwide. Some...
At ENDO 2021, the first time the Endocrine Society’s annual conference will be presented virtually, attendees can tune into the live session “Ice Ice Baby: Fertility Preservation and Restoration” to learn about the scientific advances that are enabling young cancer survivors to have genetic children. Endocrine News talks to Mary B. Zelinski, PhD, and Ina...
In transgender men, what are the consequences of gender-affirming hormonal therapy on fertility? Led by Molly B. Moravek, MD, MPH, a team of researchers from the Center for Reproductive Medicine, in Ann Arbor, Mich., set out to answer that question as well as summarize the current literature on the topic of transgender men desiring reproduction...
About a third of men with type 2 diabetes (T2D) also have hypogonadotropic hypogonadism (HH). This comorbidity makes that subgroup more insulin resistant, with increased adiposity and less lean mass, according to research published recently in The Journal of Clinical Endocrinology & Metabolism. A team led by Paresh Dandona, BSc, MB, BS, DPhil, FRCP, of...
As men age, testosterone levels decrease, but current guidelines recommend testing in symptomatic men only, and there has been a lack of consensus about what point that decrease becomes a deficiency. Healthy aging men have been presumed to have higher serum testosterone levels than their counterparts with obesity, smoking history, or associated comorbidities, but large-scale...
Testosterone supplementation prevents an increase in circulating ghrelin but does not appear to affect appetite or energy intake in healthy men who are suffering from a severe, short-term energy deficit, according to a study recently published in the Journal of the Endocrine Society. Researchers led by J. Philip Karl, PhD, RD, and Stefan M. Pasiakos,...
In his talk, “Testosterone Replacement Modalities: Pros, Cons, and Their Correct Use,” Shehzad Sultan Basaria, MD, will discuss the benefits and drawbacks of various forms of treatments so clinicians can better inform their patients with hypogonadism. By now, the controversy surrounding testosterone therapy and the shady advertising schemes promulgating the idea of “andropause” in aging...
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