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Phase 3 Trial Data Shows Positive Results for Oral Treatment of Acromegaly

Data presented last month at ENDO 2021 from Phase 3 of the MPOWERED study showed that oral octreotide capsules improved clinical symptoms and other patient-reported outcomes compared to long-acting injectable somatostatin receptor ligands (iSRLs) in patients with acromegaly. In addition, oral octreotide capsules met the pre-specified non-inferiority margin compared to long-acting iSRLs in maintenance of...
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Researchers Determine Best Predictors of Acromegaly Remission Following Transsphenoidal Surgery

Tumor size and random growth hormone concentration at diagnosis are the best predictors for remission of acromegaly after transsphenoidal surgery (TSS), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Eva C. Coopmans, MD, of Erasmus University Medical Center in Rotterdam, The Netherlands, point out that TSS...
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New Integrated Data Show Promise for Novel Thyroid Eye Disease Drug

New pooled data from Phase 2 and Phase 3 clinical trials further reinforce that teprotumumab-trbw significantly improves proptosis (eye bulging) and diplopia (double vision) for thyroid eye disease (TED) in patients in different subgroups, with most maintaining a long-term response. The results were published recently in The Lancet Diabetes & Endocrinology. Teprotumumab-trbw is a fully human...
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Researchers Develop Machine-Learning Prediction Model to Improve Medical Management of Acromegaly

Machine learning (ML), a type of artificial intelligence, could be used to predict how patients with acromegaly respond to first-generation somatostatin receptor ligands (fg-SRLs), according a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Mônica Gadelha, MD, PhD, of the Endocrine Unit and Neuroendocrinology Research Center at the Medical...
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EDC Exposure During Pregnancy May Reduce Breast Cancer Protection

ENDO_2021_4C Low doses of propylparaben — an estrogen-like chemical used as a preservative in personal care products and foods — can alter pregnancy-related changes in the breast in ways that may reduce the normal protection against breast cancer that pregnancy hormones convey, according to a new study published in Endocrinology and presented at ENDO 2021. Researchers...
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Trial Compares Two Gestational Diabetes Screening Methods

There were no significant differences in health outcomes for pregnant women who were diagnosed with gestational diabetes or their babies using two different clinically recommended screening methods, according to results from a large-scale clinical trial conducted by Kaiser Permanente researchers and published in The New England Journal of Medicine. Although there is evidence that treating...
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New Analysis Finds Cushing’s Syndrome Triples Risk of Death

Heart disease and infections rank as top causes of death among those with rare disorder Endogenous Cushing’s syndrome, a rare hormonal disorder, is associated with a threefold increase in death, primarily due to cardiovascular disease and infection, according to a study presented at ENDO 2021. The research, according to the study authors, is the largest...
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As much as we know today about the endocrine system and the effects it has on the body, there remains so much that we do not know. Discoveries are made every day, and our understanding of the endocrine system is always growing and changing. Serving patients to the best of an endocrinologist’s abilities means being aware of all the latest developments in endocrine research. This includes the newest and most complete information concerning such endocrinology research topics as new treatments and new methods for disease prevention. Identifying symptoms and making the connections between those symptoms and endocrine disease can lead to greater understanding and ultimately better treatment for patients. More advanced prevention techniques can help patients stave off disease before it can impact their lives. Having the most current information can make a tremendous difference in the quality of life for your patients.

This section features some of the most current and forward-looking articles concerning the latest research in endocrinology. Written by and for endocrinologists, these articles are provided to keep you up to date with the most relevant developments in the field of endocrinology. You can access the information you need about new technology, new treatments and general information to help you serve your patients with better overall care. Our understanding of the endocrine system is always evolving. With Endocrine News, you can ensure that your knowledge of the field won’t be left behind. What’s more, your patients will always have access to the most advanced information out there.