Derek Bagley, Author at Endocrine News

Positive Clinical Data for Oral Treatment of Acromegaly Presented at ENDO

ENDO 2022 saw the presentation of positive clinical data from the open-label extensions (OLEs) of two of the Phase 3 trials of oral octreotide for patients with acromegaly. Amryt is marketing the drug as Mycapssa. Data presented in a late-breaking poster presentation of the 2nd year of the OLE of OPTIMAL (NCT03252353), a randomized, double-blind...

New Data Show Strong Performance of Thyroid Cancer Test in Real-World Clinical Practice

Meta-analysis presented at ENDO 2022 provides real-world evidence that a test can accurately rule out thyroid cancer in patients with indeterminate thyroid nodules and that, when the test deems a nodule as suspicious, the patient’s risk of malignancy is consistent, and higher than that reported in the test’s original clinical validation (CV) study. Veracyte is...

Adult Growth Hormone Deficiency Increases Medical Costs, Risk of Additional Health Conditions

Growth hormone deficiency (GHD) among adults is associated with greater medical costs and an increased rate of other health conditions compared with those without GHD, according to industry-sponsored research presented at ENDO 2022 in Atlanta. Researchers led by Alden Smith, PharmD, Global Head of Health Economics and Outcomes Research at Ascendis Pharma in Palo Alto,...

Mouse Study Finds FGF21 Directs Body’s Responses to Low-Protein Diet

Reducing the amount of protein in the diet produces an array of favorable health outcomes, including an extension of lifespan, and that these effects depend on Fibroblast Growth Factor 21 (FGF21), according to a study recently published in Nature Communications. It has long been known that reducing the amount you eat improves health and extends...

New Study Makes Case for Culturing Embryos Up to Seven Days Post-Insemination for Selected Patients

Ending embryo culture at 144 hours (six days) post-insemination (h.p.i.) would involve 7.3 percent and 4.4 percent relative reductions in the number of patients obtaining euploid blastocysts and live birth(s) (LBs), respectively, according to a study published in Human Reproduction. The study results were announced recently by Fairtility, a company using artificial intelligence to enhance in...

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Endocrine Society Journals Earn Higher Impact Factors for 2021

The Endocrine Society’s Journals experienced sizeable Impact Factor gains, led by Endocrine Reviews, according to Clarivate’s recently released annual Journal Citation Report (JCR) for 2021. A highly regarded metric used to measure the success of scholarly journals, the 2021 Impact Factor is calculated by tracking how many times articles that a journal published in 2019...

Obesity in Pregnancy Increases Risk of Lifelong Cardiovascular Disease in Offspring

Maternal obesity impairs heart health and function of the fetus according to a new study mouse study published in The Journal of Physiology. The study found that maternal obesity causes molecular changes in the heart of the fetus and alters expression of genes related to nutrient metabolism, which greatly increases offspring’s risk of cardiac problems...

Flesh and Bone: New Research Upends the Conventional Wisdom About Body Weight and Bone Density in Men

For years, obesity was thought to have the ability to thwart the occurrence of osteoporosis, especially in men. However, a new study in The Journal of Clinical Endocrinology & Metabolism shows that men with obesity could be at a higher risk for osteoporosis than previously thought. Earlier this year, a paper entitled “Fat Mass Has...