Beta-arrestins attach themselves to outer cell membranes, waiting for hormones or neurotransmitters to land on receptors – an unexpected and surprising finding recently published in Cell. Researchers led by Davide Calebiro, MD, professor of Molecular Endocrinology in the Institute of Metabolism and Systems Research at the University of Birmingham and Co-Director of the Centre of...
Author: Derek Bagley
Mouse Study Hints at Specific Brain Receptor behind PCOS Symptoms
Deletion of androgen receptors (ARs) in leptin receptor (LepRb) neurons improves estrous cycles, providing a possible therapeutic target for the symptoms of polycystic ovarian syndrome (PCOS), according to a mouse study recently published in Endocrinology. Researchers led by Carol F. Elias, PhD, of the University of Michigan Medical School’s Department of Molecular and Integrative Physiology,...
Tirzepatide Safe and Tolerable in Treatment of Type 2 Diabetes, Researchers Find
Tirzepatide – the dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) injection used to treat type 2 diabetes – is safe and has a tolerable adverse event (AE) profile in its role in the management of T2D, and possibly obesity, according to a study recently published in the Journal of the...
Pediatric growth hormone deficiency treatments could soon be painless. Fernando Cassorla, MD, is traveling from Chile to Chicago to present research at ENDO 2023 that could potentially change the way pediatric hormone treatments are administered. If a pill could replace painful injections, patients and caregivers alike can finally wipe away their tears. A convenient, well... Weight loss achieved through the use of a combination of anti-obesity medications (AOMs) can approach the reduction seen in bariatric surgery, according to a paper recently published in JCEM Case Reports. Researchers led by Priya N. Patel, MD, of the Center for Pediatric Obesity Medicine at the University of Minnesota Medical School in Minneapolis point...
Maria T. Balhara discusses her ENDO 2023 sessions on food’s impact on human health A three-session symposium on our everchanging food environment, “Impact of the Changes in Food Environment in the Development of Obesity,” looks at endocrine-disrupting chemicals, climate change, and processing methods and how these factors impact endocrine health, specifically obesity. Endocrine News talks... The U.S. Food and Drug Administration (FDA) last month approved a new indication for somapacitan-beco injection 5 mg, 10 mg, or 15 mg for the treatment of children aged 2.5 years and older who have growth failure due to inadequate secretion of endogenous growth hormone. Novo Nordisk is marketing the treatment as Sogroya® The FDA approval...
Mutations of the Fragile X messenger ribonucleoprotein 1 gene (Fmr1) — a leading genetic cause of intellectual impairment and autism — contribute to premature ovarian failure (POF) due to changes in neurons that regulate reproduction in the brain and ovaries, according to a study recently published in Frontiers in Endocrinology. Researchers led by Djurdjica Coss,...
