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Cabergoline Tapering Successful at Maintaining Normal Prolactin Levels in Patients with Macroprolactinomas

Tapering cabergoline (CAB) levels can still maintain normal prolactin (PRL) levels in patients with macroprolactinomas, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Phillipe Chanson, MD, of Hopital de Bicetre in Le Kremlin-Bicetre, France, point out that CAB is “currently the dopamine agonist (DA) of choice” in...
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Autocrine Prolactin Associated with Endometrial Cancer Growth, Metastasis, Reduced Sensitivity to Chemotherapy

Researchers have shown that autocrine human prolactin (hPRL) promotes endometrial tumor growth and metastasis, as well as reduces sensitivity to chemotherapy, leading to worse survival outcomes. Based on this association, the investigators also point to a possible therapeutic strategy for endometrial cancer (EC). The results were published recently in Endocrinology. The team, led by Peter...
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Researchers Studying Novel Gestational Diabetes Screening Alternative

Researchers at Brigham and Women’s Hospital (BWH) recently published a study demonstrating the potential clinical utility of glycated CD59 (GCD59) as a novel biomarker for the screening and diagnosis of gestational diabetes mellitus (GDM). The data from this study showed that a single blood test that measures plasma GCD59 at week 24-28 of gestation identified...
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The Big Chill: Do Sperm Banks Need Stricter Regulations?

shutterstock_587713184 Although it sounds like a plot from a sudsy melodrama, more and more people who were conceived via sperm donation are discovering their half siblings … sometimes dozens of them! The Food & Drug Administration only regulates screening and testing donors for diseases, but many feel there needs to be more rules governing the use...
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Can Childhood Obesity be Prevented Before Conception?

First-ever exercise, nutrition program will seek answers by focusing on Cleveland mothers A Case Western Reserve University School of Medicine and MetroHealth System researcher, along with Cleveland Clinic’s director of metabolic research, have received federal funding to determine if childhood obesity can be prevented before women become pregnant. The first-ever Cleveland-based study will explore whether...
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Case of the Month: Pediatric ESAP

pediatric esap This issue highlights Pediatric Endocrine Self Assessment Program. Test your clinical knowledge and prepare for your exam. Available on the online store.   Clinical Vignette You are seeing a 16-year-old girl who just learned that she is pregnant. She is upset because she recently had an allergic skin reaction for which she was given prescription-strength...
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Appendix and Tonsil Removal Linked to Higher Pregnancy Rates

Women who had their appendix and/or tonsils removed when they were young are more likely to get pregnant, according to a study recently published in Fertility and Sterility. Not only are these women more likely to get pregnant, they get pregnant sooner. Researchers led by Sami Shimi, MD, clinical senior lecturer in the School of...