Individuals who take statins may be at higher risk for developing high blood sugar levels, insulin resistance, and eventually type 2 diabetes, according to an analysis published in the British Journal of Clinical Pharmacology. Researchers led by Prof. Bruno Stricker, of the Erasmus Medical Centre, in the Netherlands point out that while there are several epidemiological...
Genetic Studies Provide Possible Mechanistic Link Between Endometriosis and Ovarian Cancer
Genetic breakthroughs from three recent whole-exome sequencing studies of endometrial and endometriotic epithelial cells provided some unexpected findings linking endometriosis and ovarian cancer, according to a paper recently published in Endocrinology. The paper, by Serdar E. Bulun, MD, of the Feinberg School of Medicine at Northwestern University in Chicago, notes that while associations between endometriosis...
Review Examines Relationship Between Atypical Femur Fractures and Bisphosphonates
A paper recently published in Endocrine Reviews covers atypical femur fractures (AFFs) and examines their relationship with bisphosphonates (BPs), as well as prevention and treatment of these rare but devastating bone breaks. The review, by Dennis M. Black, PhD, of the University of California, San Francisco, et al, points out that BPs have been the...
Researchers Reveal Novel Mechanism in Luminal Breast Cancer Development
Researchers have identified unique isoform-specific functions of phosphorylated progesterone receptors (PRs) as pathway drivers in the development of luminal breast cancer, according to a study recently published in Endocrinology. Researchers led by Carol A. Lange, PhD, of the Masonic Cancer Center at the University of Minnesota in Minneapolis, point out that luminal, or estrogen receptor...
Review Looks at Genetic Components in Development of Hypertension
A paper recently published in Endocrine Reviews concludes that primary hypertension is not a disease but rather a syndrome, and that genetics may hold the key to targeted and individualized treatment. The review, by Worapaka Manosroi, MD, and Gordon H. Williams, MD, of Brigham and Women’s Hospital and Harvard Medical School in Boston, points out...
Childhood Exposure to Passive Smoking Linked to Impaired Bone Health in Adulthood
Children of parents who smoke have evidence of impaired bone health in adulthood, according to a study recently published in The Journal of Clinical Endocrinology and Metabolism. Researchers led by Markus Juonala, MD, PhD, of the University of Turku and Division of Medicine, Turku University Hospital, and FinlandMurdoch Childrens Research Institute in Parkville, Victoria, Australia,...
Children born in the most recent century have bones that reach full maturity earlier – by nearly 10 months in girls and nearly seven months in boys, according to a study recently published in Clinical Orthopaedics and Related Research. Researchers led by Dana Duren, PhD, director of orthopaedic research at the Thompson Laboratory for Regenerative Orthopaedics...
Most Frequent Pathogenic Mutation in RET Carries Very Low Lifetime Risk of Medullary Thyroid Cancer
The most frequent pathogenic mutation in the rearranged during transfection (RET) mutation — p.Val804Met – carries with it a very low lifetime risk of medullary thyroid cancer (MTC), which could mean the American Thyroid Association’s (ATA) recommendation of prophylactic thyroidectomy as standard for all RET mutation carriers is inappropriate, according to a study recently published...
