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The U.S. Food and Drug Administration (FDA) recently granted a New Drug Application (NDA) for a hydrocortisone oral solution Eton Pharmaceuticals, Inc. is marketing as KHINDIVI™ — a replacement therapy in pediatric patients five years of age and older with adrenocortical insufficiency. KHINDIVI is the only FDA-approved oral solution formulation of hydrocortisone. It comes in a 1mg/ml...
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“Bilateral Adrenal Leiomyomas in a Pediatric Patient,” a recently published case in JCEM Case Reports describes a highly unusual diagnosis in an 11-year-old boy: bilateral adrenal leiomyomas. These benign smooth muscle tumors are rare in any age group and typically occur unilaterally. The pediatric presentation, particularly affecting both adrenal glands, adds to the clinical rarity...
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A recent systematic review published in The Journal of Clinical Endocrinology & Metabolism confirms that early hormone therapy can effectively recreate “mini-puberty” in male infants born with congenital hypogonadotropic hypogonadism (CHH) — a rare condition characterized by insufficient hormone production during early infancy. In healthy boys, a temporary surge of hormones shortly after birth —...
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Leading pediatric endocrinologist and recipient of the Endocrine Society’s 2025 Outstanding Leadership in Endocrinology Laureate Award, Ilene Fennoy, MD, talks with Endocrine News about the potential of GLP-1s and long-term solutions for childhood obesity. She says a good place to start is creating more programs in schools to help kids eat better and incorporate more...
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Early life exposure to a class of endocrine-disrupting chemicals (EDCs) called polychlorinated biphenyls (PCBs) may lead to behavioral problems in rats, according to a new animal study published in the Journal of the Endocrine Society. Endocrine-disrupting chemicals (EDCs) are chemicals that mimic, block or interfere with hormones in the body’s endocrine system and contribute to endocrine...
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Boys and girls may equally have multiple pituitary hormone deficiencies across all levels of peak growth hormone values, according to a study recently published in Clinical Endocrinology. The paper, by Rohan K. Henry, MD, MS, et al., outlines reported biases which have long been published regarding the male predominance in patients referred to pediatric endocrinology...
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Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, according to a study presented at ENDO 2024 and published in Nature’s npj Gut and Liver. “We found that this relationship between sedentariness and liver damage is likely...
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The first global phase 2 study of vosoritide showed an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a genetic cause of short stature in children, according to a paper recently published in eClinicalMedicine. The clinical trial is funded by BioMarin. Researchers led by Andrew Dauber, MD, chief of Endocrinology at Children’s...
