Boys and girls may equally have multiple pituitary hormone deficiencies across all levels of peak growth hormone values, according to a study recently published in Clinical Endocrinology. The paper, by Rohan K. Henry, MD, MS, et al., outlines reported biases which have long been published regarding the male predominance in patients referred to pediatric endocrinology...
Children who are sedentary for more than six waking hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood, according to a study presented at ENDO 2024 and published in Nature’s npj Gut and Liver. “We found that this relationship between sedentariness and liver damage is likely...
The first global phase 2 study of vosoritide showed an average increased growth rate of 1.8 cm per year in children with hypochondroplasia, a genetic cause of short stature in children, according to a paper recently published in eClinicalMedicine. The clinical trial is funded by BioMarin. Researchers led by Andrew Dauber, MD, chief of Endocrinology at Children’s...
When two very different pediatric patients with obesity presented with unusually high leptin levels, endocrine researchers took notice and discovered that leptin was not adequately binding with receptors. When the young patients’ familial history was considered, solutions were finally forthcoming. About three years ago, a 19-month-old girl presented to Sidra Medicine – a women’s and...
Two recent studies from The Journal of Clinical Endocrinology & Metabolism emphasize the negative metabolic effects of fat mass compared with lean muscle mass on adolescent cardiovascular health and bone health. Several recent studies have highlighted the importance of lean muscle mass versus the dangers of fat mass in children and adolescents — and suggest...
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. Study author Andrew O. Agbaje, MD, MPH, FESC, talks to Endocrine News about the study’s findings, the arbitrary nature of some guidelines,...
On the 20th anniversary of the U.S. Food and Drug Administration’s approval of growth hormone (GH) treatment for idiopathic short stature (ISS), Adda Grimberg, MD, and Colin P. Hawkes, MD, PhD, both of the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, published a mini-review in The Journal...
Childhood cancer patients and survivors are at increased risk for growth disturbances, for myriad reasons, and it is important to periodically monitor their growth, according to a paper recently published in The Journal of Clinical Endocrinology & Metabolism. Tomoko Yoshida, MD, PhD, and Angela Delaney, MD, both of St. Jude Children’s Research Hospital in Memphis,...
Two recent studies from The Journal of Clinical Endocrinology & Metabolism emphasize the negative metabolic effects of fat mass compared with lean muscle mass on adolescent cardiovascular health and bone health. Several recent studies have highlighted the importance of lean muscle mass versus the dangers of fat mass in children and adolescents — and suggest...
