The issue of menopausal hormone replacement therapy (MHT) continues to confuse many clinicians, even though experts and guidelines agree that physicians should not shy away from providing estrogen to treat troublesome symptoms of menopause. The popularity of using estrogen has been swinging back and forth like a pendulum for decades. Prescriptions went on an upswing with the approval of Premarin for the prevention of osteoporosis in the 1980s and only grew in popularity...
As more and more data stack up arguing the dangers of endocrine-disrupting chemicals on human health, three new studies emphasize the damage they can do during pregnancy. As endocrine-disrupting chemicals (EDCs) gain notoriety for the havoc they wreak on human body systems, three new studies shed light on what adverse effects EDCs can have during...
Clinical trial compares preconception treatments for common cause of infertility. Weight loss and exercise improve ovulation in women who have polycystic ovary syndrome, a common hormone disorder that often causes infertility, according to a new study published in the Journal of Clinical Endocrinology & Metabolism. Polycystic ovary syndrome (PCOS) is the most common cause of...
HIGHLIGHTS
• Preeclampsia is a hypertensive disease of pregnancy that resolves only upon delivery of the baby and placenta. Although it has
been described for centuries, the cause of preeclampsia is still unknown.
• Abnormal placental development is a hallmark of preeclampsia. However, the key events in placenta formation occur at the
onset of pregnancy and thus cannot be thoroughly investigated in humans.
• Animal models of preeclampsia are valuable tools for investigating key early pregnancy events, including implantation.
• The BPH/5 murine strain spontaneously develops the cardinal signs of preeclampsia along with placental pathologies reminiscent
of the human disease. BPH/5 mice also exhibit profound periimplantation defects at the maternal-fetal interface.
• Investigating the very earliest stages of pregnancy using animal models provides the opportunities to gain insight into
dysregulated maternal and fetal interactions that may lead to preeclampsia.
• Recent advances suggest that biomarkers may be used to predict the onset of preeclampsia.
• There is evidence that circulating factors that mark the onset of preeclampsia also play an important role in the pathophysiology.
• The consequences of preeclampsia, including cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus,
and dyslipidemia require both screening and intervention.
• Studies of long-term outcomes of cardiovascular risk intervention are needed in women with a history of preeclampsia.
While some think that male reproduction is another endocrine
function that could be adversely affected by endocrinedisrupting
chemicals, not everybody is convinced. Does a
solid link between male hormones and EDCs truly exist?
The issue of menopausal hormone replacement therapy (MHT) continues to confuse many clinicians, even though experts and guidelines agree that physicians should not shy away from providing estrogen to treat troublesome symptoms of menopause. The popularity of using estrogen has been swinging back and forth like a pendulum for decades. Prescriptions went on an upswing with the approval of Premarin for the prevention of osteoporosis in the 1980s and only grew in popularity...
As more and more data stack up arguing the dangers of endocrine-disrupting chemicals on human health, three new studies emphasize the damage they can do during pregnancy. As endocrine-disrupting chemicals (EDCs) gain notoriety for the havoc they wreak on human body systems, three new studies shed light on what adverse effects EDCs can have during...
