Novel obesity treatments such as modulation of the gut microbiome and gene therapy are underutilized and could help fight the obesity epidemic, according to a new manuscript published in Endocrine Reviews. Nearly half of the adults and 20% of children in the U.S. have obesity, yet doctors are under-prescribing effective weight loss medications and many patients are not receiving the treatment they need. The weight stigma that exists in healthcare settings makes...
High-Fat Diet Impairs Circadian Rhythms in Mice, Study Finds
A high-fat diet disturbs the body clock in rat brains that normally controls satiety, leading to over-eating and obesity, according to new research published in The Journal of Physiology. This new research may be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid...
A Cleveland Clinic study demonstrates that adults with obesity lost significantly more weight when they had access to medications for chronic weight management in conjunction with their employer-based weight management program, compared to adults who did not have access to the medications. The study was published in JAMA Network Open. Obesity is a complex disease that...
Higher Fasting ‘Hunger Hormone’ Levels from Healthy Diet May Improve Heart Health and Metabolism
‘Green’ Mediterranean diet linked to elevated fasting ghrelin levels Fasting levels of the “hunger hormone” ghrelin rebound after weight loss and can help reduce belly fat and improve the body’s sensitivity to insulin, according to a study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Ghrelin is a stomach-derived hormone that stimulates...
Calling the Shot: Could a Hormonal Approach Be a Key to Treating Obesity?
A higher dose of a well-known diabetes drug has led to twice the weight loss seen with previous medications. While endocrinologists are hopeful about this new treatment, the drug may not be widely adopted since most insurers will not cover such therapies. A JAMA news article called the new formulation of semaglutide a potential...
Eating daily calories within a consistent window of 8-10 hours is a powerful strategy to prevent and manage chronic diseases such as diabetes and heart disease, according to a new manuscript published in the Endocrine Society’s journal, Endocrine Reviews. Time-restricted eating is a type of intermittent fasting that limits your food intake to a certain...
Patients Report Long-Term Favorable Effects of Weight Loss Surgery in Their Daily Lives
A new analysis from the STAMPEDE trial shows that over the course of five years, patients who had bariatric and metabolic surgery to treat uncontrolled type 2 diabetes reported greater physical health, more energy, less body pain, and less negative effects of diabetes in their daily lives, compared with patients who had medical therapy alone...
After three nights of disturbed sleep, as well as after estrogen suppression with normal or disturbed sleep, women burned significantly less fat, which could explain why menopausal women have increased rates of obesity, according to a study presented in March at ENDO 2021. Leilah Grant, PhD, of Brigham and Women’s Hospital in Boston, Mass., spoke...
