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Bad Reception: Unlocking a Confounding Enigma Behind Monogenic Obesity in Children

When two very different pediatric patients with obesity presented with unusually high leptin levels, endocrine researchers took notice and discovered that leptin was not adequately binding with receptors. When the young patients’ familial history was considered, solutions were finally forthcoming. About three years ago, a 19-month-old girl presented to Sidra Medicine – a women’s and...
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Bariatric Surgery Linked to Cardiovascular Improvements in People with Severe Obesity

Bariatric surgery may result in significant cardiometabolic improvements, particularly among younger, female, or white people and those without comorbidities, according to new research published in the Journal of the Endocrine Society. The United States has the highest obesity rates globally. In 2017 – 2018, about 40% of U.S. adults had obesity and 9% had severe obesity. The prevalence is...
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Endocrine Society Recommends Bipartisan Solutions to Senate HELP Hearing on Diabetes, Obesity

The Endocrine Society commends the Senate Health, Education, Labor, and Pensions (HELP) Committee for calling attention to the issues that are fueling the diabetes epidemic in its December 14’s hearing and urges the Committee to support bipartisan legislation to begin to address the crisis in our country. More than 38 million Americans have diabetes, and...
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FDA Approves Lilly’s Zepbound™ (tirzepatide) for Chronic Weight Management

On November 8, the U.S. Food and Drug Administration (FDA) approved Eli Lilly and Company’s (NYSE: LLY) Zepbound™ (tirzepatide) injection, the first and only obesity treatment of its kind that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. Zepbound is indicated for adults with obesity (with a BMI of 30 kg/m2 or greater), or those who...
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Endocrine Society Works to Advance Obesity Legislation in Congress

The Endocrine Society continues to be a vocal advocate to advance legislation that would address prevention and treatment of obesity. In late July, legislation known as the Treat and Reduce Obesity Act (TROA) that the Society endorsed was introduced in the House and the Senate. This important bipartisan legislation would take steps to ensure that...
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Obesity Appears to Increase the Risk of Developing Polycystic Ovary Syndrome

Obesity appears to increase the risk of developing polycystic ovary syndrome (PCOS), according to a study presented at ENDO 2023. An estimated 7% to 10% of all reproductive-aged women globally have PCOS. Women with PCOS have a hormonal imbalance and metabolism problems that may affect their overall health, appearance, and fertility. PCOS is associated with health...