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A clinical trial investigating a possible novel treatment of early-onset type 1 diabetes last month met the primary endpoint assessing the safety and tolerability of a new class of microbe-based therapeutic agents. Precigen ActoBio is evaluating this therapy — AG019 ActoBiotics — as a monotherapy and in combination with teplizumab. AG019 is formulated as an...
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About a third of men with type 2 diabetes (T2D) also have hypogonadotropic hypogonadism (HH). This comorbidity makes that subgroup more insulin resistant, with increased adiposity and less lean mass, according to research published recently in The Journal of Clinical Endocrinology & Metabolism. A team led by Paresh Dandona, BSc, MB, BS, DPhil, FRCP, of...
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The pleasure center of the brain and the brain’s biological clock are linked, and high-calorie foods — which bring pleasure — disrupt normal feeding schedules, resulting in overconsumption, according to a study recently published in Current Biology. Researchers led by Ali Güler, PhD, a professor of biology at the University of Virginia demonstrate that the...
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A drug used to treat type 2 diabetes could offer a simple and cheap solution to reduce dangerous side effects of steroid treatment, new research from Queen Mary University of London suggests. The phase 2 clinical trial, funded by Barts Charity, looked at the effects of the diabetes drug metformin on patients currently receiving high...
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Studies linking statins to diabetes receive media attention but should not distract clinicians from the goal of reducing cardiovascular risk. Almost eight years after the Food and Drug Administration (FDA) added a warning to statin labels about the drugs increasing fasting blood sugar and hemoglobin A1C levels — and by inference raising the risk of...
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Study finds eating more at breakfast instead of dinner could prevent obesity Eating a big breakfast rather than a large dinner may prevent obesity and high blood sugar, according to new research published in The Journal of Clinical Endocrinology & Metabolism. “Our results show that a meal eaten for breakfast, regardless of the amount of calories...
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Researchers in Japan have detailed a case report in which a young woman who survived childhood cancer was treated with metreleptin supplementation to improve her acquired incomplete lipodystrophy and published their findings in the Journal of the Endocrine Society. The researchers, led by Ayako Nagayama, MD, and Kenji Ashida, MD, PhD, (Nomura Laboratory) of Kurume...
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Researchers have identified a protein kinase that controls weight and homeostasis and when deficient or inactivated can lead to metabolic diseases like obesity and type 2 diabetes, according to a mouse study recently published in Endocrinology. Researchers led by Eiichi Hinoi of the Laboratory of Pharmacology in the Department of Bioactive Molecules at Gifu Pharmaceutical...
