Eureka 2020! Part I – Top Endocrine Science According to Endocrinology Editors
Digenic Variants in Fibroblast Growth Factor 21 Signaling Linked to Severe Insulin Resistance
Variants in genes that mediate fibroblast growth factor 21 – a hormone secreted by the liver that acts to regulate the body’s response to starvation – have for the first time been linked to severe insulin resistance, according to a paper recently published in the Journal of the Endocrine Society. Researchers led by Stephen Stone,...
Insulin Titration Software Combined with CGM Enables Patients with Diabetes to Improve Time in Range
First study to utilize CGM data with FDA-cleared, cloud-based titration software suggests significantly improved outcomes for patients while optimizing clinical resources This past summer, Glytec published the first proof-of-concept study that combines FDA-cleared remote insulin titration software and data from continuous glucose monitoring (CGM) systems. Results of the study, presented at the American Diabetes Association’s...
Positive Topline Results Announced in Type 1 Diabetes Clinical Trial
A clinical trial investigating a possible novel treatment of early-onset type 1 diabetes last month met the primary endpoint assessing the safety and tolerability of a new class of microbe-based therapeutic agents. Precigen ActoBio is evaluating this therapy — AG019 ActoBiotics — as a monotherapy and in combination with teplizumab. AG019 is formulated as an...
Insulin Sensitivity Improves with Testosterone Therapy in Men with Type 2 Diabetes and Hypogonadism
About a third of men with type 2 diabetes (T2D) also have hypogonadotropic hypogonadism (HH). This comorbidity makes that subgroup more insulin resistant, with increased adiposity and less lean mass, according to research published recently in The Journal of Clinical Endocrinology & Metabolism. A team led by Paresh Dandona, BSc, MB, BS, DPhil, FRCP, of...
Study Finds Dopamine, Biological Clock Link to Snacking, Overeating, and Obesity
The pleasure center of the brain and the brain’s biological clock are linked, and high-calorie foods — which bring pleasure — disrupt normal feeding schedules, resulting in overconsumption, according to a study recently published in Current Biology. Researchers led by Ali Güler, PhD, a professor of biology at the University of Virginia demonstrate that the...
Diabetes Drug Reduces Complications of Long-Term Steroid Therapy
A drug used to treat type 2 diabetes could offer a simple and cheap solution to reduce dangerous side effects of steroid treatment, new research from Queen Mary University of London suggests. The phase 2 clinical trial, funded by Barts Charity, looked at the effects of the diabetes drug metformin on patients currently receiving high...
Studies linking statins to diabetes receive media attention but should not distract clinicians from the goal of reducing cardiovascular risk. Almost eight years after the Food and Drug Administration (FDA) added a warning to statin labels about the drugs increasing fasting blood sugar and hemoglobin A1C levels — and by inference raising the risk of...
Diabetes Research Articles
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