An Endocrine News roundup of the week’s pharmaceutical news, breakthroughs, and general information. * Corcept’s Phase 3 Long-Term Extension Study of Relacorilant Demonstrated Durable Cardiometabolic Improvements in Patients with Hypercortisolism Corcept Therapeutics Incorporated, a commercial-stage company engaged in the discovery and development of medications to treat severe endocrinologic, oncologic, metabolic, and neurologic disorders by modulating...
HDL Quality, Not Quantity, Contributes to the First Sign of Alzheimer’s Disease in Women
Higher levels of HDL-C—known as the “good cholesterol”—have been shown to correlate with heightened risk for Alzheimer’s disease, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Once women reach the menopause transition, it’s a matter of the quality, rather than quantity, of the total cholesterol carried by HDL particles circulating in a...
Review Examines Cardiometabolic Aspects of Congenital Adrenal Hyperplasia
A paper recently published in Endocrine Reviews takes a look at the cardiometabolic risk in patients with congenital adrenal hyperplasia (CAH), since patients with CAH who are being treated still face numerous complications and increased mortality. The authors of the review (Krysiak et al) write that the aim of their article is to create an...
Moderate Coffee and Caffeine Consumption Linked to Lower Risk of Cardiometabolic Diseases
Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease, and stroke, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Researchers found that regular coffee or caffeine intake, especially at moderate levels, was associated...
Pregnant Women Exposed to PFAS May Be at Risk for Obesity, Heart Disease Later in Life
Women with higher levels of per- and polyfluoroalkyl substances (PFAS) during pregnancy may experience long-term weight gain and heart problems later in life, according to new research published in The Journal of Clinical Endocrinology & Metabolism. PFAS are manmade chemicals found in food packaging, cookware, clothes, drinking water, personal care products and many other consumer goods. These endocrine-disrupting...
Bariatric Surgery Linked to Cardiovascular Improvements in People with Severe Obesity
Bariatric surgery may result in significant cardiometabolic improvements, particularly among younger, female, or white people and those without comorbidities, according to new research published in the Journal of the Endocrine Society. The United States has the highest obesity rates globally. In 2017 – 2018, about 40% of U.S. adults had obesity and 9% had severe obesity. The prevalence is...
Having a Ball: What Can Be Done About Pediatric Dyslipidemia?
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. Study author Andrew O. Agbaje, MD, MPH, FESC, talks to Endocrine News about the study’s findings, the arbitrary nature of some guidelines,...Children Who Are Sedentary May Have a Higher Risk of Heart Attack or Stroke Later in Life
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. High cholesterol during childhood has been associated with early signs of heart disease when individuals reach their mid-twenties and an increased risk of...
