When two very different pediatric patients with obesity presented with unusually high leptin levels, endocrine researchers took notice and discovered that leptin was not adequately binding with receptors. When the young patients’ familial history was considered, solutions were finally forthcoming. About three years ago, a 19-month-old girl presented to Sidra Medicine – a women’s and...
Two recent studies from The Journal of Clinical Endocrinology & Metabolism emphasize the negative metabolic effects of fat mass compared with lean muscle mass on adolescent cardiovascular health and bone health. Several recent studies have highlighted the importance of lean muscle mass versus the dangers of fat mass in children and adolescents — and suggest...
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. Study author Andrew O. Agbaje, MD, MPH, FESC, talks to Endocrine News about the study’s findings, the arbitrary nature of some guidelines,...
On the 20th anniversary of the U.S. Food and Drug Administration’s approval of growth hormone (GH) treatment for idiopathic short stature (ISS), Adda Grimberg, MD, and Colin P. Hawkes, MD, PhD, both of the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, published a mini-review in The Journal...
Childhood cancer patients and survivors are at increased risk for growth disturbances, for myriad reasons, and it is important to periodically monitor their growth, according to a paper recently published in The Journal of Clinical Endocrinology & Metabolism. Tomoko Yoshida, MD, PhD, and Angela Delaney, MD, both of St. Jude Children’s Research Hospital in Memphis,...
The increase in free insulin-like growth factor (IGF)-I levels in prepubertal children with Prader-Willi Syndrome (PWS) treated with exogenous growth hormone (GH) could be caused by increased pregnancy-associated plasma protein A (PAPP-A, PAPP-A2) levels and a reduction in stanniocalcins (STC-1, STC-2), according to a study recently published in The Journal of Clinical Endocrinology & Metabolism....
Children who are physically inactive may have high cholesterol in early adulthood and subsequent heart health issues in their mid-forties, according to new research published in The Journal of Clinical Endocrinology & Metabolism. High cholesterol during childhood has been associated with early signs of heart disease when individuals reach their mid-twenties and an increased risk of...
A new Journal of the Endocrine Society study highlights how to identify children at high risk of developing type 2 diabetes and strategies for prevention, such as anti-obesity or anti-diabetes medication and lifestyle changes. Prediabetes is a health condition in which blood sugar levels are higher than normal, but not yet high enough to be diagnosed as...
Two recent studies from The Journal of Clinical Endocrinology & Metabolism emphasize the negative metabolic effects of fat mass compared with lean muscle mass on adolescent cardiovascular health and bone health. Several recent studies have highlighted the importance of lean muscle mass versus the dangers of fat mass in children and adolescents — and suggest...
