Researchers in Norway have found very little incidence of end-stage renal disease (ESRD) among those with childhood-onset type 1 diabetes who were followed for up to 42 years, according to a study recently published in Diabetes Care.
Researchers led by Torild Skrivarhaug, PhD, of Oslo University Hospital, evaluated patient data for a follow-up period of up to 42 years post-diagnosis. Information was collected from the Norwegian Childhood Diabetes Registry (NCDR), a nationwide, population-based registry of childhood-onset T1D (diagnosis before 15 years of age) in Norway. Data from a total of 7,871 people — 4,242 males and 3,629 females — with T1D was included. Retrospective data was collected on 1,888 people diagnosed with T1D from January 1973 to December 1982, and prospective data was collected on 5,983 people who were diagnosed with T1D from January 1989 to December 2012. Beginning in 1989, all T1D cases have been registered prospectively in the NCDR.
Study follow-up was completed until one of the following: patient development of ESRD, death, emigration, or completion of the study in 2015. Researchers estimated the cumulative incidence of ESRD by linking to the Norwegian Renal Registry and used the Kaplan-Meier method to estimate the cumulative incidence of ESRD by years since diagnosis of T1D.
The study found a very low incidence of ESRD among patients with childhood-onset diabetes in Norway, with 103 of 7,871 people (1.3%) developing ESRD. The average time from diagnosis of T1D to development of ESRD was 25.9 years. The cumulative incidence of ESRD was 0.7% at 20 years diabetes duration; 2.9% at 30 years duration; and 5.3% at 40 years duration. The risk of ESRD was lower in women compared to men and was lower in individuals diagnosed at a younger age
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