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Researchers may have come across a novel treatment target to treat the rare but aggressive cancer adrenocortical carcinoma (ACC), according to a study recently published in Endocrinology. The researchers, led by Wiebke Arlt and Paul A. Foster, both of the University of Birmingham in the United Kingdom, write that the mitochondrial NADPH generator Nicotinamide Nucleotide...
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Patients with multiple endocrine neoplasia type 1 (MEN1) suffer from a fear of disease occurrence that is associated with a lower quality of life, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Gerlof D. Valk, MD, PhD, of the University Medical Center Utrecht in the Netherlands,...
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Understanding how the circadian clock, as well as key clock proteins, affect the formation and accumulation of adipose tissue could be another front in the battle against obesity, according to a paper recently published in Endocrine Reviews. The review, by Oren Froy, of the Hebrew University of Jerusalem in Rehovot, Israel, and Marta Garaulet, of...
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Inhibiting cellular senescence could be a novel therapeutic strategy to prevent bone loss and other age-related diseases, according to a mini-review recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Sundeep Khosla, MD, of the Mayo Clinic in Rochester, Minn., write that while life expectancy now is longer than ever, age-related...
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Significant differences in health status and cardiometabolic health exist between transgender adults and cisgender adults in the United States, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Natalie J. Nokoff, MD, of the University of Colorado Denver Anschutz Medical Campus in Aurora, point out that 0.5 percent...
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Androgen receptor (AR) signaling is responsible for key reproductive and metabolic polycystic ovary syndrome (PCOS) phenotypes, according to animal study, the results of which were published recently in Endocrinology. Researchers led by Pamela L. Mellon, PhD, of the University of California, San Diego, point out that animal models have proven to be a valuable resource...
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Alterations in the myocardial ghrelin-GHSR1a system may predict diabetic cardiomyopathy (DCM), according to a study recently published in the Journal of the Endocrine Society. Researchers led by Savita Dhanvantari, PhD, of the Lawson Health Research Institute in London, Ontario point out that DCM is characterized by progressive cardiac dysfunction, and that the early stages of...
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Researchers may have discovered a factor that contributes to racial discrepancies in developing Alzheimer’s disease (AD) or dementia, according to a study recently published in The Journal of Clinical Endocrinology and Metabolism. Researchers led by Antonio C. Bianco, MD, PhD, of University of Chicago, point out that a common single nucleotide polymorphism in DIO2, Thr92AlaD2, is...
