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The Hidden Hepatotoxicity of Zoledronic Acid

jcemcr_2_5cover The safety profile of zoledronic acid (ZOL), a powerful bisphosphonate widely used for osteoporosis and metastatic bone diseases in cancer patients, has historically been regarded as well-established. Common side effects such as fever, myalgia, and flu-like symptoms are manageable and transient. However, a recent case report in the JCEM Case Reports journal highlights a rare...
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Following Up: Could a New Pharmacological Treatment Provide Hope for Hypoparathyroidism Patients?

Approved a little more than a year ago by the U.S. Food and Drug Administration, palopegteriparatide was lauded by a panel of experts from around the world in a recently published consensus statement on hypoparathyroidism treatment. Aliya Khan, MD, talks to Endocrine News what this means for these patients’ treatment options, quality of life, and...
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String of Pearls: A Look at Rare Clinical Pearls from JCEM Case Reports

The JCEM Case Reports Clinical Pearls session at ENDO 2025 featured three presentations of rare challenging endocrine cases that could answer questions for endocrinologists who could be treating patients with similar symptoms, possibly triggering further investigations that might lead to optimal outcomes.  The audience for the third-annual JCEM Case Reports Clinical Pearls session at ENDO...
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Osteoporosis Treatment Rates Rise, But Millions Still Fall Through Cracks

A new study in The Journal of Clinical Endocrinology & Metabolism has revealed a concerning paradox in the management of osteoporosis in the United States. While the use of drug therapies for the bone-weakening disease has increased over the last decade, a significant and persistent trend of underdiagnosis means millions of high-risk patients are missing...
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Closing the Gap: Highlighting FLS for Osteoporosis Management

Divya Sistla, MD, FACP, a steering committee member of the Endocrine Society’s Early-Career Special Interest Group (SIG), discusses how the University of Pittsburgh Medical Center uses a multidisciplinary approach to successfully improve osteoporosis treatment via a fracture liaison service. In the United States, approximately 2 million new cases of osteoporotic fractures are diagnosed annually. This...