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Volanesorsen Shown to Reduce Triglyceride Levels in Patients with Severe Hypertriglyceridemia

Last month, our team presented data showing apolipoprotein C-III (apoC-III) inhibition with a RNA-targeted antisense therapy called volanesorsen effectively lowered triglycerides in patients with hypertriglyceridemia by 70%. This data was presented today at the National Lipid Association annual meeting in Philadelphia. Volanesorsen is designed to reduce the production of apoC-III, a protein produced in the...
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Bariatric Surgery or Medication/Lifestyle Modifications: Which Has Better Long-Term Effect on Type 2 Diabetes? Cleveland Clinic-Led Multicenter Trial to Assess Approaches

$10.2 million NIH grant to support first long-term study A team of Cleveland Clinic researchers is leading a first-of-its-kind multicenter clinical trial to assess the long-term outcomes of bariatric/metabolic surgery compared to medical and lifestyle therapy for treating Type 2 diabetes. The Alliance of Randomized Trials of Medicine versus Metabolic Surgery in Type 2 Diabetes...
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Weighing Options: Obesity Treatment Guideline Emphasizes Prevention

shutterstock_122081065-rev With the number of children with obesity at epidemic levels, clinicians need to redouble prevention efforts — and even get involved in advocating policies to fight obesogenic environments. Prevention is the best hope for combating pediatric obesity because current treatments are limited in efficacy, according to a new Endocrine Society guideline. “Intensive, family-centered lifestyle modifications...
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Short, High-Intensity Exercise Sessions Improve Insulin Production in Type 2 Diabetes

Short, functional-movement and resistance training workouts, called functional high-intensity training (F-HIT) may improve beta-cell function in adults with type 2 diabetes, according to a study recently published in the American Journal of Physiology—Endocrinology and Metabolism. Researchers led by John P. Kirwan, PhD, of Cleveland Clinic, point out that previous research has shown that aerobic exercise...
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Adolescent Obesity Linked to Early Mortality from Cardiovascular Diseases

New Israeli study shows even BMIs in normal range associated with increased cardiovascular risk While there is solid evidence that adolescent overweight and obesity are associated with coronary heart disease (CHD) and stroke, less is known about the association between body mass index (BMI) and rarer cardiovascular diseases. A new large-scale, 45-year Israeli study published...
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Endocrine Society Issues Scientific Statement on Obesity’s Causes

Statement calls for studying factors that undermine long-term weight maintenance A new Scientific Statement issued by the Endocrine Society calls for more research aimed specifically at understanding the underlying mechanisms that make it difficult to maintain long-term weight loss. Despite decades of research and billions of dollars spent each year on treatment, understanding of the...
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Cabergoline Tapering Successful at Maintaining Normal Prolactin Levels in Patients with Macroprolactinomas

Tapering cabergoline (CAB) levels can still maintain normal prolactin (PRL) levels in patients with macroprolactinomas, according to a study recently published in the Journal of the Endocrine Society. Researchers led by Phillipe Chanson, MD, of Hopital de Bicetre in Le Kremlin-Bicetre, France, point out that CAB is “currently the dopamine agonist (DA) of choice” in...