New data highlights how cold exposure activates brown fat, energy metabolism
Short-term cold exposure may help people with brown fat burn 15 percent more calories than those without, according to a small study published in The Journal of Clinical Endocrinology & Metabolism.
Unlike white fat, brown fat burns calories through fatty acid oxidation and heat production and is considered a promising target in the fight against the obesity epidemic. The biggest activator of brown fat is moderate cold exposure.
“This data improves our understanding of how brown fat works in humans,” says the study’s corresponding author, Florian W. Kiefer, MD, PhD, of the Medical University of Vienna in Austria. “We found that individuals with active brown fat burned 20 more kilocalories than those without.”
The researchers identified two groups using a PET scan—those with and without active brown fat. They analyzed brown fat function and energy expenditure in these individuals before and after short-term cold exposure finding that the group with active brown fat not only burned significantly more calories but had a healthier fatty acid blood profile.
“We have to study human brown fat in more detail to see if this organ can protect us against metabolic and cardiovascular disease,” Kiefer says.
Other authors include: Oana C. Kulterer, Carsten T. Herz, Alexander R. Haug, Dietmar Pils, and Alexandra Kautzky-Willer of the Medical University of Vienna; and Laura Niederstaetter, Andrea Bileck, and Christopher Gerner of the University of Vienna in Austria.
The study was supported by the Vienna Science and Technology Fund, the Austrian Science Fund and the Austrian Diabetes Association Research Fund.
The manuscript, “The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans,” was published online, ahead of print.