The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at www.endocrine.org.
Fat Quality and Incident Cardiovascular Disease, All-Cause Mortality and Cancer Mortality • Klara J. Rosenquist, Joseph M. Massaro, Alison Pedley, Michelle T. Long, Bernard E. Kreger, Ramachandran S. Vasan, Joanne M. Murabito, Udo Hoff mann, and Caroline S. Fox • Fat quality, as estimated by CT attenuation, is associated with all-cause mortality, non-CVD death, and cancer death. Th ese associations highlight how indirect indices of fat quality can potentially add to a better understanding of obesity-related complications.
Serum Thyroglobulin (Tg) Monitoring of Patients with Differentiated Thyroid Cancer (DTC) using Sensitive (Second-Generation) Immunometric Assays (Tg2GIMA) Can Be Disrupted by False-Negative and False-Positive Serum Thyroglobulin Autoantibody (TgAb) Misclassifications • Carole Spencer, Ivana Petrovic, Shireen Fatemi, and Jonathan LoPresti • Reliable detection of interfering TgAb is method and cutoff dependent. No cutoff eliminated both false-negative and false-positive TgAb misclassifications. Functional sensitivity cutoffs were optimal for minimizing falsenegatives, but have inherent imprecision (20%CV) that, exacerbated by TgAb biologic variability during DTC monitoring, could cause TgAb status to fluctuate for low TgAb patients, prompting unnecessary Tg method changes and disrupting Tg monitoring. Laboratories using reflexing should limit Tg method changes by considering patient Tg+TgAb history in addition to current TgAb status before Tg method selection.
Prenatal Influence of an Androgen Agonist and Antagonist on the Differentiation of the Ovine Sexually Dimorphic Nucleus in Male and Female Lamb Fetuses • Charles E. Roselli, Radhika Reddy, Charles Estill, Melissa Scheldrup, Mary Meaker, Fred Stormshak, and Hernán J. Montilla • Th is article concludes that, during the critical period, the male reproductive axis in long gestation species, such as sheep, is suffi ciently developed to react to perturbations in serum androgens and mitigate disruptions in brain masculinization.
Direct Regulation of Gonadotropin Release by Neurokinin B in Tilapia (Oreochromis niloticus) • J. Biran, M. Golan, N. Mizrahi, S. Ogawa, I. S. Parhar, and B. Levavi-Sivan • The results of this study suggest that the members of the NKB/tac3r system may serve as paracrine/autocrine regulators of gonadotropin release in fi sh pituitary.
Eukaryotic Initiation Factor 5A Plays an Essential Role in Luteinizing Hormone Receptor Regulation • Bindu Menon, Th ippeswamy Gulappa, and K. M. J. Menon • This study for the first time reveals the crucial role of eIF5A and its hypusination in the regulation of LH receptor expression in the ovary.
Minireview: Steroid/Nuclear Receptor-Regulated Dynamics of Occluding and Anchoring Junctions • Gary L. Firestone and Bhumika J. Kapadia • The focus of this minireview is to discuss molecular, cellular, and physiological studies that directly link nuclear receptor- and ligand-triggered signaling pathways to the regulation of occluding and anchoring junction dynamics.
A Natural Androgen Receptor Antagonist Induces Cellular Senescence in Prostate Cancer Cells • Wiebke Hessenkemper, Julia Roediger, Sophie Bartsch, Adriaan B. Houtsmuller, Martin E. van Royen, Iver Petersen, Marc-Oliver Grimm, and Aria Baniahmad • Taken together, these data indicate that AA exhibits novel features to inhibit AR amino/carboxy-terminal interaction, the AR-mediated nuclear activities and growth of PCa cells.
Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors • Erin E. Mulvihill and Daniel J. Drucker • Th is article reviews data identifying the roles of key DPP4 substrates in transducing the glucoregulatory, anti-infl ammatory, and cardiometabolic actions of DPP4 inhibitors in both preclinical and clinical studies. Finally, it highlights experimental pitfalls and technical challenges encountered in studies designed to understand the mechanisms of action and downstream targets activated by inhibition of DPP4.
Implications of Prenatal Steroid Perturbations for NeuroDevelopment, Behavior, and Autism • Andrea C. Gore, Katherine M. Martien, Khatuna Gagnidze, and Donald Pfaff • The purposes of this review are: (i.) to summarize some consequences of steroid exposures during pregnancy for the development of brain and behavior in the off spring; (ii.) to summarize what is known about the relationships between exposures and behavior, including autism spectrum disorders; (iii.) to discuss the molecular underpinnings of such effects, especially molecular epigenetic mechanisms of prenatal steroid manipulations, a field that may explain effects of direct exposures, and even transgenerational effects; and (iv.) for all of these, to add cautionary notes about their interpretation in the name of scientific rigor.