New Endocrine Society Clinical Practice Guideline Examines Better Ways to Manage Hypoglycemia in People with Diabetes

People with diabetes are benefiting from advances in medications and technologies to lower their risk of hypoglycemia, according to a Clinical Practice Guideline issued today by the Endocrine Society.

The guideline, titled “Management of Individuals with Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline,” was published online and will appear in the March 2023 print issue of The Journal of Clinical Endocrinology & Metabolism (JCEM), a publication of the Endocrine Society.

Hypoglycemia is the term for episodes of dangerously low blood sugar in people with diabetes. Patients with severe hypoglycemia may experience unconsciousness or seizures, and the condition can significantly affect a person’s quality of life, social life, work productivity and ability to drive safely. It is common in people with type 1 diabetes, and in those with 2 diabetes who are taking insulin or sulfonylureas, and many people do not experience or recognize the symptoms.

Hypoglycemia is identified as one of the top three preventable adverse drug reactions by the U.S. Department of Health and Human Services. Between January 2007 and December 2011, emergency department visits for therapy-associated hypoglycemia among Medicare beneficiaries resulted in more than $600 million in spending.

“People with diabetes, their caregivers, and diabetes specialists will all benefit from our guideline with a better understanding of best practices and interventions.”

Anthony L. McCall, MD, PhD, University of Virginia, Charlottesville, Va.


This guideline updates the Society’s 2009 inpatient hypoglycemia guideline and focuses solely on people with diabetes-related hypoglycemia. It incorporates recommendations to treat and manage hypoglycemia more effectively using new insulins and forms of glucagon, and advancements in continuous glucose monitoring (CGM) and insulin pump technology.

“CGMs and insulin pumps have been much more commonly used in the last decade among people with diabetes including children, and there are new forms of glucagon available. We had to update our guideline to match these developments in the diabetes field,” says Anthony L. McCall, MD, PhD, of the University of Virginia in Charlottesville, Va. McCall is the chair of the panel that wrote the guideline. “People with diabetes, their caregivers, and diabetes specialists will all benefit from our guideline with a better understanding of best practices and interventions.”

Key recommendations from the guideline include: 

  • Prescribing easier-to-use formulations of glucagon for people with severe hypoglycemia; 
  • Leveraging CGM rather than self-monitoring of blood glucose by fingerstick for patients with type 1 diabetes receiving multiple daily injections;
  • Conducting inpatient glycemic surveillance and management programs leveraging electronic health record (EHR) data for inpatients at risk for hypoglycemia; and
  • Utilizing structured patient education programs for adult and pediatric patients with type 1 diabetes or type 2 diabetes receiving insulin therapy.

Additional guideline resources include the Endocrine News Q&A with the co-chairs and the Society’s hypoglycemia patient resources.

Other members of the Endocrine Society writing committee that developed this guideline include: David C. Lieb (co-chair) of Eastern Virginia Medical School in Norfolk, Va.; Roma Gianchandani of Cedars Sinai in Los Angeles, Calif.; Heidemarie MacMaster of Lahey Health in Burlington, Mass.; Gregory A. Maynard of the University of California Davis in Davis, Calif.; M. Hassan Murad of Mayo Clinic in Rochester, Minn.; Elizabeth Seaquist of the University of Minnesota in Minneapolis, Minn.; Joseph I. Wolfsdorf of Boston Children’s Hospital in Boston, Mass.; Robin Fein Wright of DiabetesSisters in Bolingbrook, Ill.; and Wojtek Wiercioch of McMaster University in Hamilton, Ontario.

Victor Torres Roldan of the Mayo Evidence-Based Practice Center conducted the evidence reviews for the guideline, and Drs. Jane Seley and Grazia Aleppo made significant scientific contributions. Maureen Corrigan, director for Clinical Practice Guidelines for the Endocrine Society assisted with all aspects of guideline development.

The Society established its Clinical Practice Guideline Program to provide endocrinologists and other clinicians with evidence-based recommendations in the diagnosis, treatment, and management of endocrine-related conditions. Each guideline is developed by a multidisciplinary panel of topic-related experts in the field. Guideline development panels rely on evidence-based reviews of the literature in the development of guideline recommendations. The Endocrine Society does not solicit or accept corporate support for its guidelines. All Clinical Practice Guidelines are supported entirely by Society funds.

This Clinical Practice Guideline was co-sponsored by the American Association of Clinical Endocrinology, the American Diabetes Association, DiabetesSisters, the Pediatric Endocrine Society, and the Society for Hospital Medicine.

Williams is the senior manager, Communications, for the Endocrine Society. In the September Endocrine News, she wrote about the EndoCares event that took place in Clarkston, Ga., during ENDO 2022 in Atlanta.

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