Cover Story
February 2015

Family History: Advances in Genetic Testing

Advances in genetic testing have been crucial to discovering the underlying causes of many endocrine disorders. They not only act as a guide to treatment but also as a precaution for family members.

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  • Pearls of Wisdom: Experts Lead Career Activities at ENDO2015

    Early Career Activities at ENDO 2015 will highlight the ins and outs of getting published, finding a mentor, and so much more that you probably weren’t taught in medical school.

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  • Preeclampsia: A Multi-Faceted Look at This Puzzling Condition

    HIGHLIGHTS • Preeclampsia is a hypertensive disease of pregnancy that resolves only upon delivery of the baby and placenta. Although it has been described for centuries, the cause of preeclampsia is still unknown. • Abnormal placental development is a hallmark of preeclampsia. However, the key events in placenta formation occur at the onset of pregnancy and thus cannot be thoroughly investigated in humans. • Animal models of preeclampsia are valuable tools for investigating key early pregnancy events, including implantation. • The BPH/5 murine strain spontaneously develops the cardinal signs of preeclampsia along with placental pathologies reminiscent of the human disease. BPH/5 mice also exhibit profound periimplantation defects at the maternal-fetal interface. • Investigating the very earliest stages of pregnancy using animal models provides the opportunities to gain insight into dysregulated maternal and fetal interactions that may lead to preeclampsia. • Recent advances suggest that biomarkers may be used to predict the onset of preeclampsia. • There is evidence that circulating factors that mark the onset of preeclampsia also play an important role in the pathophysiology. • The consequences of preeclampsia, including cardiovascular disease, cerebrovascular disease, hypertension, diabetes mellitus, and dyslipidemia require both screening and intervention. • Studies of long-term outcomes of cardiovascular risk intervention are needed in women with a history of preeclampsia.

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  • Straight Talk: A Personal Journey Through Acromegaly

    When radio personality Froggy was diagnosed with acromegaly 10 years ago, he made it his personal mission to educate the public — as well as primary care physicians — on this rare and unexpected disease.

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  • Team Spirit: Is a Group Practice Right for You?

    The decision to go from your own practice to working for a group or a hospital requires thought and planning… and preparing for the worst.

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  • Lab Equipment: Buy, Lease, or Rent?

    Whether you should buy or rent your equipment depends on the type of research you’re doing, how often the equipment will be used, and a variety of other considerations.

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