RESEARCH BRIEFS

The following studies will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals via www.endo-society.org.

Hepcidin inhibition by E2 increases iron uptake, compensating for iron loss during menstruation; this mechanism may also contribute to increased iron stores in oral contraceptive users. Yang Q, Jian J, Katz S, Abramson SB, Huang X. 17beta-estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site.

Total α1AMPK deficiency in male mice affects androgen production and spermatozoa quality, leading to a decrease in fertility. Using an AMPK activator such as metformin could jeopardize human male fertility. Tartarin P, Guibert E, Toure A, et al. Inactivation of AMPK alpha1 induces asthenozoospermia and alters spermatozoa morphology.

The intermediate filament vimentin moves cholesterol from the cytoplasm to the mitochondria for steroidogenesis. Shen W-J, Zaidi SK, Patel S, et al. Ablation of vimentin results in defective steroidogenesis.

Nucleobindin-2 regulates epithelial growth factor–stimulated MEK/Erk signaling, cell proliferation, and adipocyte differentiation. Tagaya Y, Miura A, Okada S, Ohshima K, Mori M. Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation.

SREs are just as common in thyroid cancer patients as in those with metastatic breast cancer, necessitating the need for antiresorptive therapy. Farooki A, Leung V, Tala H, Tuttle RM. Skeletal-related events due to bone metastases from differentiated thyroid cancer.

LPO is linked to periodontal disease susceptibility in T2DM patients. de Souza Bastos A, Graves DT, de Melo Loureiro AP, et al. Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes.

Steroidogenic factor-1 mutations are frequently found in 46, XY DSD individuals and manifest with a broad phenotype. Camats N, Pandey AV, FernándezCancio M, et al. Ten novel mutations in the NR5A1 gene cause disordered sex development in 46,XY and ovarian insufficiency in 46,XX individuals.

Down-regulation of a specific subset of miRNAs leads to pituitary tumorigenesis. D’Angelo D, Palmieri D, Mussnich P, et al. Altered microRNA expression profile in human pituitary GH adenomas: Downregulation of miRNAs targeting HMGA1, HMGA2, and E2F1.

Tsc22d3-2–deficient male mice are infertile, exhibit severe testis dysplasia, increases in apoptotic cells within seminiferous tubules, a heightened number of Leydig cells, and a significantly elevated follicle-stimulating hormone and testosterone levels. Suarez PE, Rodriguez EG, Soundararajan R, et al. The glucocorticoid-induced leucine zipper (Gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.

Several genes are regulated by various tissue-selective estrogen complex combinations, but not by an estrogen or selective estrogen receptor modulator alone. Wardell SE, Kazmin D, McDonnell DP. Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERMs and between SERM/estrogen complexes.

FOXO1 deregulation may contribute to macrovascular complications in poorly controlled diabetes. Cifarelli V, Lee S, Kim DH, et al. FOXO1 mediates the autocrine effect of endothelin-1 on endothelial cell survival.

Loss of heterozygosity is the most prevalent second allele–inactivating event in both syndromic and sporadic pheochromocytomas. Weber A, Hoffmann MM, Neumann HPH, Erlic Z. Somatic mutation analysis of the SDHB, SDBC, SDHD, and RET genes in the clinical assessment of sporadic and hereditary pheochromocytoma.

Giannoulis MG, Martin FC, Nair KS, Umpleby AM, Sonksen P. Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?

Vandenberg LN, Colborn T, Hayes TB, et al. Hormones and endocrine-disrupting chemicals: Low-Dose effects and nonmonotonic dose responses.

Rosen CJ, Adams JS, Bikle DD, et al. The nonskeletal effects of vitamin D: An Endocrine Society scientific statement.

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