Studies in the Society journals

The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at

Risk of Developing Diabetes and Cardiovascular Disease in Metabolically Unhealthy Normal-Weight and Metabolically Healthy Obese Individuals • KoKo Aung, Carlos Lorenzo, Marco A. Hinojosa, and Steven M. Haffner • The risk of developing DM and CVD is increased in MUH-NW and MHO individuals. Screening for obesity and other metabolic abnormalities should be routinely performed in clinical practice to institute appropriate preventive measures.

Insulin-Like Peptide 3 (INSL3) in Men With Congenital Hypogonadotropic Hypogonadism/Kallmann Syndrome and Effects of Different Modalities of Hormonal Treatment: A Single-Center Study of 281 Patients • Séverine Trabado, Luigi Maione, Hélène Bry-Gauillard, Hélène Affres, Sylvie Salenave, Julie Sarfati, Claire Bouvattier, Brigitte Delemer, Philippe Chanson, Yves Le Bouc, Sylvie Brailly-Tabard, and Jacques Young • INSL3 is as sensitive a marker as T for the evaluation of altered Leydig cell function in CHH/KS patients. INSL3 levels correlate with LH levels in CHH/ KS men showing, together with the rise in INSL3 levels during hCG therapy, that INSL3 secretion seems not constitutively secreted during adulthood but is dependence on pituitary LH.

Muscle Anatomy and Dynamic Muscle Function in Osteogenesis Imperfecta Type I • Louis-Nicolas Veilleux, Martin Lemay, Annie Pouliot-Laforte, Moira S. Cheung, Francis H. Glorieux, and Frank Rauch • Children and adolescents with OI type I have, on average, a significant force deficit in the lower limb as measured by dynamic force tests. Nonetheless, these data also show that OI type I is compatible with normal muscle performance in some individuals.

TGF-{beta}1 Regulation of Multidrug Resistance P-glycoprotein in the Developing Male Blood-Brain Barrier • Stephanie Baello, Majid Iqbal, Enrrico Bloise, William Gibb, and Stephen G. Matthews • TGF-β1 regulates P-gp at the fetal and neonatal BBB, and both ALK5 and ALK1 pathways are implicated in the regulation of P-gp function. Aberrations in TGF-β1 levels at the developing BBB may lead to substantial changes in fetal brain exposure to P-gp substrates, triggering consequences for brain development.

Synergistic Activation of Steroidogenic Acute Regulatory Protein Expression and Steroid Biosynthesis by Retinoids: Involvement of cAMP/PKA Signaling • Pulak R. Manna, Andrzej T. Slominski, Steven R. King, Cloyce L. Stetson, and Douglas M. Stocco • These findings delineate the molecular events by which retinoids influence cAMP/PKA signaling and provide additional and novel insight into the regulation of StAR expression and steroidogenesis in mouse Leydig cells.

Steroidogenic Factor 1 Promotes Aggressive Growth of Castration Resistant Prostate Cancer Cells by Stimulating Steroid Synthesis and Cell Proliferation • Samantha R. Lewis, Curtis J. Hedman, Toni Ziegler, William A. Ricke, and Joan S. Jorgensen • SF1 stimulates steroid accumulation and stabilizes centrosome homeostasis to mediate aggressive prostate cancer cell growth within a castrate environment. These findings present a new molecular mechanism and therapeutic target for deadly CRPC.

The Intestinal Epithelial Insulin-Like Growth Factor-1 Receptor Links Glucagon-Like Peptide-2 Action to Gut Barrier Function • Charlotte X. Dong, Wen Zhao, Chloe Solomon, Katherine J. Rowland, Cameron Ackerley, Sylvie Robine, Martin Holzenberger, Tanja Gonska, and Patricia L. Brubaker • The effects of GLP-2 on intestinal barrier function are dependent on the IE-IGF-1R and involve modulation of key components of the tight junctional complex.

Cell-Specific Actions of a Human LHX3 Gene Enhancer During Pituitary and Spinal Cord Development • Soyoung Park, Rachel D. Mullen, and Simon J. Rhodes • The human LHX3 enhancer-driven Cre reporter transgenic mice also provide a valuable tool for further developmental studies of cell determination and differentiation in the pituitary and nervous system.

Hepatic-Specific Accessibility of Igf1 Gene Enhancers Is Independent of Growth Hormone Signaling • Mahalakshmi Santhanam and Dennis J. Chia • Robust GH-stimulated hepatic Igf1 gene transcription utilizes tissue-specific mechanisms of epigenetic regulation that are established independent of GH signaling.

M-Protein Is Down-Regulated in Cardiac Hypertrophy Driven by Thyroid Hormone in Rats • Andrei Rozanski, Ana Paula C. Takano, Patricia N. Kato, Antonio G. Soares, Camilo Lellis-Santos, Juliane Cruz Campos, Julio Cesar Batista Ferreira, Maria Luiza M. Barreto-Chaves, and Anselmo S. Moriscot • The M-protein expression is strongly and rapidly repressed by T3 in cardiomyocytes, which represents an important aspect for the basis of T3-dependent sarcomeric deleterious effects in the heart.

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