Endocrine Society members David J. Mangelsdorf, PhD; Erica Elizabeth Marsh, MD, MSCI; and Margaret M. McCarthy, PhD have been elected to the National Academy of Medicine (NAM).
David J. Mangelsdorf, PhD, is professor and chair, department of pharmacology, and investigator, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas. He was noted for his landmark discoveries of oxysterol (LXRs) and bile acid (FXR) nuclear receptors that revealed the sensing mechanisms that govern reverse cholesterol transport and bile acid synthesis. He co-discovered the key roles of the endocrine hormones FGF21 and FGF15/19 in regulating lipid and energy metabolism, and bile acid homeostasis, respectively.
Mangelsdorf also received the Endocrine Society’s 2025 Edwin B. Astwood Award for Outstanding Research in Basic Science with Steven Kliewer, PhD, for groundbreaking discoveries in endocrine signaling through nuclear receptor research.
Erica Elizabeth Marsh, MD, MSCI, is the S. Jan Behrman Collegiate Professor of Reproductive Medicine, vice chair and division chief, reproductive endocrinology and infertility, department of obstetrics and gynecology, University of Michigan Medical School, Ann Arbor. For research on uterine leiomyomas and for her efforts to eliminate disparities in reproductive health. Her commitment to building research capacity in women’s health, both nationally and globally, and her cultivation of the next generation of leaders in reproductive health will have a lasting impact.
Margaret M. McCarthy, PhD, is the director, University of Maryland – Medicine Institute for Neuroscience Discovery; and James and Carolyn Frenkil Dean’s Endowed Professor and distinguished university professor, department of pharmacology, physiology, and drug development, University of Maryland School of Medicine, Baltimore. She was recognized for being the first to discover a critical role of the immune system in determining sex differences and the impact of infection and inflammation on neuroanatomical and behavioral outcomes, which provided mechanistic insights into the higher prevalence of autism spectrum disorders and schizophrenia in boys and men.
Election to the Academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.
“This class of new members represents the most exceptional researchers and leaders in health and medicine, who have made significant breakthroughs, led the response to major public health challenges, and advanced health equity,” says NAM President Victor J. Dzau. “Their expertise will be necessary to supporting NAM’s work to address the pressing health and scientific challenges we face today. It is my privilege to welcome these esteemed individuals to the National Academy of Medicine.”
New members are elected by current members through a process that recognizes individuals who have made major contributions to the advancement of the medical sciences, health care, and public health. A diversity of talent among NAM’s membership is assured by its Articles of Organization, which stipulate that at least one-quarter of the membership is selected from fields outside the health professions — for example, from such fields as law, engineering, social sciences, and the humanities. The newly elected members bring NAM’s total membership to more than 2,400, which includes nearly 200 international members.
Established originally as the Institute of Medicine in 1970 by the National Academy of Sciences, the National Academy of Medicine addresses critical issues in health, science, medicine, and related policy and inspires positive actions across sectors. NAM works alongside the National Academy of Sciences and National Academy of Engineering to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The National Academies of Sciences, Engineering, and Medicine also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding of STEMM. With their election, NAM members make a commitment to volunteer their service in National Academies activities.
For the full list of 2024 NAM inductees, click here.
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