Society Journal Studies

The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s
Early Release section. You can access the journals at www.endocrine.org.

Subclinical Vascular Dysfunction Associated with Metabolic Syndrome in African Americans and Whites • Jia Shen, Joseph C. Poole, Matthew L. Topel, Aurelian Bidulescu, Alanna A. Morris, Riyaz S. Patel, Jose G. Binongo, Sandra B Dunbar, Lawrence Phillips, Viola Vaccarino, Gary H. Gibbons, and Arshed A. Quyyumi • Although MetS is associated with microvascular dysfunction and increased arterial stiffness in both racial groups, AA without MetS have greater vascular dysfunction compared to whites. Additional weighting for hypertension in AA attenuated the racial diff erences in subclinical disease associated with MetS.

Radioactive Iodine Therapy Did Not Significantly Increase the Incidence and Recurrence of Subsequent Breast Cancer • Hwa Young Ahn, Hye Sook Min, Yohwan Yeo, Seung Hyun Ma, Yunji Hwang, Jee Hyun An, Hoon Sung Choi, Bhumsuk Keam, Seock-Ah Im, Do Joon Park, In Ae Park, Dong-Young Noh, Yeo-Kyu Youn, June-Key Chung, Bo Youn Cho, Sue K. Park, and Young Joo Park • The long-term follow-up results of this study suggest that RAI treatment for thyroid cancer patients may not increase the risk or recurrence of breast cancer.

Lower Preprandial Insulin and Altered Fuel Utilization in HIV/Antiretroviral-Exposed Infants in Cameroon • Jennifer Jao, Brian Kirmse, Chunli Yu, Yunping Qiu, Kathleen Powis, Emmanuel Nshom, Fanny Epie, Pius Muffih Tih, Rhoda S. Sperling, Elaine J. Abrams, Mitchell E. Geffner, Derek LeRoith, and Irwin J. Kurland • HEU-A and HEU-N infants have lower preprandial insulin levels at six weeks of age and appear to utilize metabolic fuel substrates differently than HUU infants. Future studies are warranted to determine whether observed differences have lasting metabolic implications, such as later insulin resistance.

Osteocalcin Effect on Human Beta Cells Mass and Function • Omaima M. Sabek, Satoru Ken Nishimoto, Daniel Fraga, Neelam Tejpal, Camillo Ricordi, and A.O. Gaber • These data for the first time show decarboxylated osteocalcin-enhanced β-cell function in human islets and support future exploitation of decarboxylated osteocalcin-mediated β-cell regulation for developing useful clinical treatments for patients with diabetes.

Sympathetic Nerve Activity Maintains an Anti-infl ammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages • Lijun Tang, Shiki Okamoto, Tetsuya Shiuchi, Chitoku Toda, Kazuyo Takagi, Tatsuya Sato, Kumiko Saito, Shigefumi Yokota, and Yasuhiko Minokoshi • These results show that the SNS and β2-AR–PKA pathway maintain an anti-inflammatory state in ATMs of lean mice in vivo, and that the brain melanocortin pathway plays a role in maintaining this state in WAT of lean mice via the SNS.

The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life • Hyeran Jang, Shalender Bhasin, Tyler Guarneri, Carlo Serra, Mary Schneider, Mi-Jeong Lee, Wen Guo, Susan K. Fried, Karol Pencina, and Ravi Jasuja • Collectively, these data suggest that sustained reproductive and metabolic alterations may result in female mice from a transient exposure to testosterone during a narrow postnatal developmental window.

TNF-α Suppressed FSH-Induced LH Receptor Expression through Transcriptional Regulation in Rat Granulosa Cells • Kohshiro Nakao, Hiroshi Kishi, Fumiharu Imai, Hiroto Suwa, Takashi Hirakawa, and Takashi Minegishi • Taken together, these results suggest that the interaction of NF-βB p65 with HDAC in the promoter region of rat Lhcgr might be responsible for TNF-α action on the regulation of LHR.

Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction and COX2 Induction in Type 2 Diabetes Mellitus • Ji-Youn Youn, Jun Zhou, and Hua Cai • Taken together, these data for the first time reveal a novel role of BMP4 in inducing NOX1-dependent eNOS uncoupling in T2DM, which may promote development of new therapeutics restoring endothelial function in T2DM.

The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are not Humans • Christian Sell • This review examines the differences in the insulin/IGF-1 axis between invertebrate and mammalian systems and discusses implications of these differences in terms of lifespan modulation.

COPII Dependent ER Export: a Critical Component of Insulin Biogenesis and Beta Cell ER Homeostasis • Jingye Fang, Ming Liu, Xuebao Zhang, Takeshi Sakamoto, Douglas J. Taatjes, Bhanu P. Jena, Fei Sun, James Woods, Tim Bryson, Anjaneyulu Kowluru, Kezhong Zhang, and Xuequn Chen • Collectively, results from this study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and beta cell survival.