RESEARCH BRIEFS

The following studies will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals via www.endo-society.org.

VSG performed in prediabetic UC Davis-Type 2 Diabetes Mellitus rats delays disease onset by improving islet function and decreasing circulating lipids. Cummings BP, Bettaieb A, Graham JL, et al. Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats.

Estrogen receptor α plays a role in hearing-related behavior. Charitidi K, Meltser I, Canlon B. Estradiol treatment and hormonal fluctuations during the estrous cycle modulate the expression of estrogen receptors in the auditory system and the prepulse inhibition of acoustic startle response.

Elderly subjects might benefit from ghrelin treatment to inhibit osteoclastogenesis and improve bone structure. van der Velde M, van der Eerden BCJ, Sun Y, et al. An age-dependent interaction with leptin unmasks ghrelin’s bone-protective effects.

Cdc80-deficient mice fed highfat diets have metabolic abnormalities similar to prediabetes: hyperglycemia, glucose intolerance, and impaired insulin secretion. Tremblay F, Huard C, Dow J, et al. Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.

MAS-associated gonadal pathology is not significantly more common in females than males. Boyce AM, Chong WH, Shawker TH, et al. Characterization and management of testicular pathology in McCune-Albright syndrome.

Mid-life weight gain leads to changes in sex steroids rather than the converse. Wildman RP, Tepper PG, Crawford S, et al. Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from The Study of Women’s Health Across the Nation.

Osteoblast progenitor cell maturation is inhibited in T2DM patients. Manavalan JS, Cremers S, Dempster DW, et al. Circulating osteogenic precursor cells in type 2 diabetes mellitus.

Over the last 15 years, BRAFV600E mutations have been seen more often than RET/PTC rearrangements in PTC patients. Romei C, Fugazzola L, Puxeddu E, et al. Modifications in the papillary thyroid cancer gene profile over the last 15 years.

E2 promotes the secretion of stromal cell–derived enolase 1, which associates with PCa cells and activates plasminogen, thereby promoting extracellular matrix remodeling and cancer cell migration. Yu L, Shi J, Chen S, et al. Estrogen promotes prostate cancer cell migration via paracrine release of ENO1 from stromal cells.

At term, low levels of PTB-associated splicing factor contribute to increased myometrial contractionassociated protein gene expression and to labor onset by removing the repressive function of progesterone on the myometrium. Xie N, Liu L, Li Y, et al. Expression and function of myometrial PSF suggest a role in progesterone withdrawal and the initiation of labour.

Secretin receptors play a proliferative role, via the P13K/ AKT signaling pathway, in pheochromocytoma and adrenocortical carcinoma cells. Lee M, Waser B, Reubi J-C, Pellegata NS. Secretin receptor promotes the proliferation of endocrine tumor cells via the P13K/AKT pathway.

Cancer BioChip Systems could be used in personalized targeted cancer therapy. Abbud-Antaki RA, Marhefka JN, DeLuca AL, Zuromskis MP. The Cancer BioChip System: A functional genomic assay for anchorage-independent three-dimensional breast cancer cell growth.

Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: A review of current evidence.

Böhm M, Grässel S. Role of proopiomelanocortin-derived peptides and their receptors in the osteoarticular system. From basic to translational research.

Brooks CL. Molecular mechanisms of prolactin and its receptor.

Prudente S, Sesti G, Pandolfi A, Andreozzi F, Consoli A, Trischitta V. The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.

Stefater MA, Wilson-Peréz HE, Chambers AP, Sandoval DA, Seeley RJ. All bariatric surgeries are not created equal: Insights from mechanistic comparisons.

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