Studies in the Society journals

The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at www.endocrine.org

Toll-Like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective • Ishwarlal Jialal, Harmeet Kaur, and Sridevi Devaraj • In this review, we present evidence for a pivotal role of TLR-induced inflammation in both obesity and MetS and speculate that targeting these TLRs can forestall their adverse sequelae of diabetes and CVD.

A Cross-Sectional Study of the Prevalence of Cardiac Valvular Abnormalities in Hyperprolactinemic Patients Treated with Ergot-Derived Dopamine Agonists • W.M. Drake, C.E. Stiles, T.A. Howlett, A.A. Toogood, J.S. Bevan, and R.P. Steeds • This large UK cross-sectional study does not support a clinically concerning association between the use of dopamine agonists for the treatment of hyperprolactinemia and cardiac valvulopathy

Subclinical Hypothyroidism and Left Ventricular Mechanics: A ThreeDimensional Speckle Tracking Study • Marijana Tadic, Sanja Ilic, Nada Kostic, Zorica Caparevic, and Vera Celic • SHT significantly affects LV deformation assessed by 2DE and 3DE speckle tracking. The improvement of LV mechanics after one-year levothyroxine treatment is significant, but incomplete.

Five-Year Relative Survival of Patients With Osteoporotic Hip Fracture • Young-Kyun Lee, You-Jin Lee, Yong-Chan Ha, and Kyung-Hoi Koo • Results showed that five-year relative survival after osteoporotic hip fracture was below those of the general populations and was comparable with some cancers, like thyroid and breast cancer. Therefore, osteoporotic hip fracture should not be overlooked.

Analysis of Glucocorticoid Receptors and Their Apoptotic Response to Dexamethasone in Male Murine B Cells During Development • Amanda L. Gruver-Yates, Matthew A. Quinn, and John A. Cidlowski • Th e data suggest that glucocorticoid signaling has an important understudied role in B-cell life-or-death decisions.

Gonadal Steroid Modulation of Sleep and Wakefulness in Male and Female Rats Is Sexually Differentiated and Neonatally Organized by Steroid Exposure • Danielle M. Cusmano, Maria M. Hadjimarkou, and Jessica A. Mong • Together our data suggest that, like sex behavior, sex diff erences in sleep follow the classical organizational/activational effects of gonadal steroids.

Impaired Glucocorticoid Production and Response to Stress in ArntlDefi cient Male Mice • Alexei Leliavski, Anton Shostak, Jana Husse, and Henrik Oster • Arntl disruption, probably via its effect on adrenal clock function, modulates stress axis activity and, thus, may promote resistance to both acute and repeated stress.

Role of Calcium and EPAC in Norepinephrine-Induced Ghrelin Secretion • Bharath K. Mani, Jen-Chieh Chuang, Lilja Kjalarsdottir, Ichiro Sakata, Angela K. Walker, Anna Kuperman, Sherri Osborne-Lawrence, Joyce J. Repa, and Jeffrey M. Zigman • Constitutive ghrelin secretion is primarily regulated by Ca2+ influx through L-type VGCCs and that NE stimulates ghrelin secretion predominantly through release of intracellular Ca2+. Furthermore, cAMP and its downstream activation of EPAC are required for the normal ghrelin secretory response to NE.

STAT3 Regulates Uterine Epithelial Remodelling and Epithelial-Stromal Crosstalk During Implantation • Sandeep Pawar, Elina Starosvetsky, Grant D. Orvis, Richard R. Behringer, Indrani C. Bagchi, and Milan K. Bagchi • Collectively, our results uncovered an intricate molecular network operating downstream of STAT3 that regulates uterine epithelial junctional reorganization, and stromal proliferation and differentiation, which are critical determinants of successful implantation.

COUP-TFII Regulates Human Endometrial Stromal Genes Involved in Inflammation • Xilong Li, Michael J. Large, Chad J. Creighton, Rainer B. Lanz, Jae-Wook Jeong, Steven L. Young, Bruce A. Lessey, Wilder A. Palomino, Sophia Y. Tsai, and Francesco J. DeMayo • The determination that COUP-TFII plays a role in inflammation may add insight into the role of COUP-TFII in embryo implantation and in endometrial diseases such as endometriosis.

Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element • Liesbeth Clinckemalie, Lien Spans, Vanessa Dubois, Michaël Laurent, Christine Helsen, Steven Joniau, and Frank Claessens • The presence of this SNP might have implications on the expression and/or formation levels of TMPRSS2 fusions, since both have been shown to be influenced by androgens.

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