The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at www.endocrine.org.
Increased Brain Transport and Metabolism of Acetate in Hypoglycemia Unawareness Barbara I. Gulanski, Henk M. De Feyter, Kathleen A. Page, Renata Belfort de Aguiar, Graeme F. Mason, Douglas L. Rothman, and Robert S. Sherwin • Increased MCA transport and metabolism among T1DM individuals with hypoglycemia unawareness may be a mechanism to supply the brain with non-glucose fuels during episodes of acute hypoglycemia and may contribute to the syndrome of hypoglycemia unawareness, independent of diabetes.
Central Hypothyroidism and Its Replacement Have a Signifi cant Influence on Cardiovascular Risk Factors in Adult Hypopituitary Patients M. Klose, D. Marina, M. L. Hartoft-Nielsen, O. Klefter, V. Gavin, L. Hilsted, Å.K. Rasmussen, and U. Feldtrasmussen • Th is single-center study over a 20-year period has strengthened the importance of improved awareness of thyroid status and optimal thyroid replacement of hypopituitary patients in order to reduce cardiovascular risks in hypopituitary patients.
Insulin Resistance and Impaired Pancreatic Beta-Cell Function in Adult Offspring of Women with Diabetes in Pregnancy Louise Kelstrup, Peter Damm, Elisabeth R. Mathiesen, Torben Hansen, Allan A. Vaag, Oluf Pedersen, and Tine D. Clausen • Reduced insulin sensitivity as well as impaired pancreatic beta-cell function may contribute to the increased risk of glucose intolerance among adult off spring born to women with diabetes during pregnancy.
Uncovering Novel Roles of Non-Neuronal Cells in Body Weight Homeostasis and Obesity Julie A. Chowen, Jesús Argente, and Tamas L. Horvath • Th is minireview focuses on the recent advances in our understanding of how glial cells participate in the physiological regulation of appetite and systemic metabolism, as well as their role in the pathophysiological response to poor nutrition and secondary complications associated with obesity
Chemerin Suppresses Ovarian Follicular Development and Its Potential Involvement in Follicular Arrest in Rats Treated Chronically with Dihydrotestosterone Ji Young Kim, Kai Xue, Mingju Cao, Qi Wang, Jia-yin Liu, Arthur Leader, Jae Yong Han, and Benjamin K. Tsang • The findings are consistent with authors’ hypothesis that antral follicular growth arrest in DHT-treated rats results from increased chemerin expression and action, as well as changes in follicular cell fate and structure, which are a consequence of dysregulated interactions of pro-survival and pro-apoptotic modulators in a cell-specific manner. Their observations suggest that this chronically androgenized rat model may be useful for studies on the long-term effects of androgens on folliculogenesis and may have implications for the female reproductive disorders associated with hyperandrogenism
Peripheral Androgen Receptors Sustain the Acrobatics and Fine Motor Skill of Elaborate Male Courtship Matthew J. Fuxjager, Kristy M. Longpre, Jennifer G. Chew, Leonida Fusani, and Barney A. Schlinger • Together, the findings help differentiate the various effects of peripheral and central AR on the performance of a complex socio-sexual behavioral phenotype, while indicating that peripheral AR can optimize the motor skills necessary for the production of an elaborate animal display.
Kisspeptin Regulates Gonadotropin Genes via Immediate Early Gene Induction in Pituitary Gonadotropes Emily A. Witham, Jason D. Meadows, Hanne M. Hoffmann, Shadi Shojaei, Djurdjica Coss, Alexander S. Kauffman, and Pamela L. Mellon • Overall, the findings indicate that kisspeptin regulates gonadotropin gene expression through the activation of Kiss1R signaling through PKC, inducing immediate early genes in vitro, and responds to physiologically relevant cues in vivo, suggesting that kisspeptin aff ects pituitary gene expression to regulate reproductive function.
Novel, Gel-Free Proteomics Approach Identifies RNF5 and JAMP as Modulators of GPCR Stability Sébastien J. Roy, Irina Glazkova, Louis Fréchette, Christian IorioMorin, Chantal Binda, Darlaine Pétrin, Phan Trieu, Mélanie Robitaille, Stéphane Angers, Terence E. Hébert, and Jean-Luc Parent • Th e data suggest that RNF5 regulates the turnover of specifi c GPCRs by ubiquitinating JAMP and preventing proteasome recruitment.
New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget’s Disease of Bone Sarah L. Rea, John P. Walsh, Robert Layfield, Thomas Ratajczak, and Jiake Xu • Th e purpose of this review is to outline recent advances in understanding of the multiple pathophysiological roles of SQSTM1/ p62 protein, with particular emphasis on their relationship to PDB, including challenges associated with translating SQSTM1/p62 research into clinical diagnosis and treatment.