Studies in the Society journals

The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at

Lifestyle and Metformin Treatment Favorably Influence Lipoprotein Subfraction Distribution in the Diabetes Prevention Program • Ronald Goldberg, Marinella Temprosa, James Otvos, John Brunzell, Santica Marcovina, Kieren Mather, Richard Arakaki, Karol Watson, Edward Horton, and Elizabeth Barrett-Connor • Intensive lifestyle change and metformin treatment have favorable effects on lipoprotein subfractions that are primarily mediated by intervention-related changes in insulin resistance, BMI, and adiponectin. Interventions that slow the development of diabetes may also retard the progression of atherosclerosis.

Circadian Clock Characteristics Are Altered in Human Thyroid Malignant Nodules • Tiphaine Mannic, Patrick Meyer, Frederic Triponez, Marc Pusztaszeri, Gwendal Le Martelot, Olivia Mariani, Daniel Schmitter, Daniel Sage, Jacques Philippe, and Charna Dibner • Characterization of the thyroid clock machinery alterations upon thyroid nodule malignant transformation contributes to understanding the connections between circadian clocks and oncogenic transformation. Moreover, it might help in improving the thyroid nodule pre-operative diagnostics.

Trial of Recombinant Follicle Stimulating Hormone (rFSH) Pre-treatment for GnRH-induced Fertility in Patients with Congenital Hypogonadotropic Hypogonadism • Andrew A. Dwyer, Gerasimos P. Sykiotis, Frances J. Hayes, Paul A. Boepple, Hang Lee, Kevin R. Loughlin, Martin Dym, Patrick M. Sluss, William F. Crowley Jr., and Nelly Pitteloud • rFSH pre-treatment followed by GnRH is successful in inducing testicular growth and fertility in CHH men with prepubertal testes. rFSH not only appears to maximize the SC population, but also induces morphologic changes suggesting broader developmental roles.

The Heparin-Binding Domains of IGFBP-2 Mediate Its Inhibitory Effect on Preadipocyte Differentiation and Fat Development in Male Mice • Gang Xi, Melissa A. Solum, Christine Wai, Laura A. Maile, Clifford J. Rosen, and David R. Clemmons • Th e HBD2 domain of IGFBP-2 is the primary region that accounts for its ability to inhibit adipogenesis and that a peptide encompassing this region has activity that is comparable with native IGFBP-2.

Human Resistin in ChemotherapyInduced Heart Failure in Humanized Male Mice and in Women treated for Breast Cancer • Daniel R. Schwartz, Erika R. Briggs, Mohammed Qatanani, Heloisa Sawaya, Igal A. Sebag, Michael H. Picard, Marielle ScherrerCrosbie, and Mitchell A. Lazar • Elevated resistin is a biomarker of anthracycline-induced cardiotoxicity and may contribute in the development of heart failure via its direct effects on macrophages. These results further implicate resistin as a link between inflammation, metabolism, and heart disease.

ERβ Selective Agonist Inhibits Angiotensin-Induced Cardiovascular Pathology in Female Mice • Ali Pedram, Mahnaz Razandi, Kenneth S. Korach, Ramesh Narayanan, James T. Dalton, and Ellis R. Levin • Th e findings provide additional understanding of the antihypertrophic effects of ERβ and serve as an impetus to test specific receptor agonists in humans to prevent the worsening of cardiovascular disease.

Determinants of the Heightened Activity of Glucocorticoid Receptor Translational Isoforms • Ingrid K. Bender, Yun Cao, and Nick Z. Lu • These studies, together with the observations that GR isoforms have a cell-specific expression pattern, provide a molecular basis for the tissue-specific functions of GR translational isoforms.

Infarct-Induced Steroidogenic Acute Regulatory Protein: a Survival Role in Cardiac Fibroblasts • Eli Anuka, Natalie Yivgi-Ohana, Sarah Eimerl, Benjamin Garfinkel, Naomi Melamed-Book, Elena Chepurkol, Dan Aravot, Tova Zinman, Asher Shainberg, Edith Hochhauser, and Joseph Orly • Post-infarction expression of non-steroidogenic StAR in cardiac fibroblasts has a novel anti-apoptotic activity allowing myofibroblast precursor cells to survive the traumatized event, probably in order to differentiate and function in tissue repair at the infarction site.

Key Role of CRF in the Skin Stress Response System • Andrzej T. Slominski, Michal A. Zmijewski, Blazej Zbytek, Desmond J. Tobin, Theoharis C. Theoharides, and Jean Rivier • CRF and CRFR-1 may constitute novel targets through the use of specific agonists or antagonists especially for therapy of skin diseases that worsen with stress, such as atopic dermatitis and psoriasis.

Thyroid Hormone, Thyromimetics, and Metabolic Efficiency • Einav YehudaShnaidman, Bella Kalderon, and Jacob Bar-Tana • Permeability transition pore (PTP) gating may offer a unified target for some TH pleiotropic activities and may serve as a novel target for synthetic functional thyromimetics designed to modulate metabolic efficiency. PTP gating by long-chain fatty acid analogs may serve as a model for such strategy.

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