Studies in the Society journals

The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at

Approach to the Patient With Oligozoospermia Robert I. McLachlan The clinical approach to the oligozoospermic man involves understanding reproductive endocrinology, aspects of urology and clinical genetics, modern ART options, and the realistic discussion of their outcomes, alternatives such as adoption or donor gametes, and appreciation of the psychosocial concerns of the couple.

Outcome of Surgical Treatment of 200 Children With Cushing’s Disease Russell R. Lonser, Joshua J. Wind, Lynnette K. Nieman, Robert J. Weil, Hetty L. DeVroom, and Edward H. Oldfield Early postoperative endocrine testing predicts lasting Cushing’s disease remission. Because lasting remission is associated with younger age at surgery, smaller adenomas, and lack of dural invasion, early diagnosis should improve surgical outcome.

Clinical Review: Parathyroid Localization and Implications for Clinical Management John W. Kunstman, Jonathan D. Kirsch, Amit Mahajan, and Robert Udelsman Parathyroid localization is indicated in surgical candidates. Crucial considerations when selecting an imaging study include availability, cost, radiation exposure, local expertise, and accuracy.

Active Vitamin D (1,25-Dihydroxyvitamin D) and Bone Health in MiddleAged and Elderly Men: The European Male Aging Study Dirk Vanderschueren, Stephen R. Pye, Terence W. O’Neill, David M. Lee, Ivo Jans, Jaak Billen, Evelien Gielen, Michaël Laurent, Frank Claessens, Judith E. Adams, Kate A. Ward, Gyorgy Bartfai, Felipe F. Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Th ang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E. J. Lean, Neil Pendleton, Margus Punab, Frederick C. W. Wu, Steven Boonen, and the EMAS Study Group Serum 1,25(OH)2D is associated with higher bone turnover and poorer bone health despite being positively related to 25(OH)D. A combination of high 1,25(OH)2D and low 25(OH) D is associated with the poorest bone health.

Obesity: A Somatotrope Perspective Buffy S. Ellsworth Leptin acts as an indicator of energy stores and regulates appetite through regulation of orexogenic and anorexogenic signals in the hypothalamus.

Organizational Effects of Perinatal Exposure to Bisphenol-A and Diethylstilbestrol on Arcuate Nucleus Circuitry Controlling Food Intake and Energy Expenditure in Male and Female CD-1 Mice Harry MacKay, Zachary R. Patterson, Rim Khazall, Shoyeb Patel, Dina Tsirlin, and Alfonso Abizaid Early-life exposure to the obesogen BPA leads to sexually dimorphic alterations in the structure of hypothalamic energy balance circuitry, leading to increased vulnerability for developing diet-induced obesity and metabolic impairments, such as glucose intolerance.

Posttranslational Processing of Human and Mouse Urocortin 2: Characterization and Bioactivity of Gene Products Joan M. Vaughan, Cynthia J. Donaldson, Wolfgang H. Fischer, Marilyn H. Perrin, Jean E. Rivier, Paul E. Sawchenko, and Wylie W. Vale Probable urocortin 2 processing products were identified and should expedite the characterization of these proteins in mammalian tissues.

Androgens Promote Prostate Cancer Cell Growth Through Induction of Autophagy Yan Shi, Jenny J. Han, Jayantha B. Tennakoon, Fabiola F. Mehta, Fatima A. Merchant, Alan R. Burns, Matthew K. Howe, Donald P. McDonnell, and Daniel E. Frigo Th ere is a role for increased fat metabolism and autophagy in prostatic neoplasias.

FOXO1/3 Depletion in Granulosa Cells Alters Follicle Growth, Death, and Regulation of Pituitary FSH Zhilin Liu, Diego H. Castrillon, Wei Zhou, and JoAnne S. Richards FOXO1/3 divergently regulates follicle growth or death by interacting with the activin or BMP pathways in granulosa cells and by modulating pituitary FSH production.

HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered β-Catenin Switch Zixue Jin, Wei Wei, Paul C. Dechow, and Yihong Wan HDAC7 deletion in the osteoclast lineage results in a 26% reduction in bone mass owing to a 102% elevated bone resorption.

The Roles of Vitamin D in Skeletal Muscle: Form, Function, and Metabolism Christian M. Girgis, Roderick J. Clifton-Bligh, Mark W. Hamrick, Michael F. Holick, and Jenny E. Gunton.

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications Evanthia Diamanti-Kandarakis and Andrea Dunaif.

Sclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases Hua Zhu Ke, William G. Richards, Xiaodong Li, and Michael S. Ominsky.

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