Studies in the Society journals

The following studies will be published in Endocrine Society journals. Before print, they are edited and posted online, in each journal’s Early Release section. You can access the journals via www.endo-society.org.

Theca cell–derived BMP4 and BMP7 down-regulate Cx43 expression and decrease GJIC activity in human granulosa cells. This biological effect is most likely mediated by a Smad-dependent pathway. Chang, Hsun-Ming; Cheng, Jung-Chien; Leung, Peter C.K. Theca-Derived BMP4 and BMP7 Down-Regulate Connexin43 Expression and Decrease Gap Junction Intercellular Communication Activity in Immortalized Human Granulosa Cells.

Osteocalcin level might be an independent indicator of cardiovascular risk and global health in elderly Caucasian men. Confavreux, Cyrille B.; Szulc, Pawel; Casey, Romain; Boutroy, Stéphanie; Varennes, Annie; Vilayphiou, Nicolas; Goudable, Joelle; Chapurlat, Roland D. Higher Serum Osteocalcin Is Associated With Lower Abdominal Aortic Calcification Progression and Longer 10-Year Survival in Elderly Men of the MINOS Cohort.

Women with PCOS have higher global adiposity and increased amounts of visceral adipose tissue compared with control women, especially in the ip and mesenteric depots. Borruel, Susana; Fernández-Durán, Elena; Alpañés, Macarena; Martí, David; Álvarez-Blasco, Francisco; Luque-Ramírez, Manuel; EscobarMorreale, Héctor F. Global Adiposity and Th ickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS).

KLLN might be used as a potential prognostic marker for risk management and as a novel therapy target for advanced prostate carcinomas. Wang, Yu; Radhakrishnan, Deepa; He, Xin; Peehl, Donna M.; Eng, Charis. Transcription Factor KLLN Inhibits Tumor Growth by AR Suppression, Induces Apoptosis by TP53/TP73 Stimulation in Prostate Carcinomas, and Correlates With Cellular Differentiation.

Mig6 may be a novel target for preventing glucocorticoidinduced impairments in functional ß-cell mass. Holloway, Kimberly R.; Barbieri, Andreia; Malyarchuk, Svitlana; Saxena, Madhurima; Nedeljkovic-Kurepa, Ana; Mehl, Mathieu Cameron; Wang, Allison; Gu, Xin; Pruitt, Kevin. SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.

GR dimers play important role in anti-inflammatory actions of GCs/ GR. Vandevyver, Sofi e; Dejager, Lien; Tuckermann, Jan; Libert, Claude. New Insights Into the Anti-inflammatory Mechanisms of Glucocorticoids: An Emerging Role for GlucocorticoidReceptor-Mediated Transactivation.

Dual inhibitors of PI3K and mTOR may enhance alkylating agent-mediated cytotoxicity and provide a novel regimen in the treatment of invasive PAs. Dai, Congxin; Zhang, Bo; Liu, Xiaohai; Ma, Sihai; Yang, Yakun; Yao, Yong; Feng, Ming; Bao, Xinjie; Li, Guilin; Wang, Janxin; Guo, Kai; Ma, Wenbin; Xing, Bing; Lian, Wei; Xiao, Jianqi; Cai, Feng; Zhang, Hongbin; Wang, Renzhi. Inhibition of PI3K/AKT/mTOR Pathway Enhances TemozolomideInduced Cytotoxicity in Pituitary Adenoma Cell Lines in Vitro and Xenografted Pituitary Adenoma in Female Nude Mice.

Hypothalamic and/or mesocorticolimbic dopaminergic circuits are targets for hormonal activation of social reward. Bell, Margaret R.; Sisk, Cheryl L. Dopamine Mediates Testosterone-Induced Social Reward in Male Syrian Hamsters.

New critical components of the CRHR1 signaling machinery, which selectively controls the early and late phases of ERK1/2 activation, are identifi ed, providing new potential therapeutic targets for stress-related disorders. Bonfi glio, Juan J.; Inda, Carolina; Senin, Sergio; Maccarrone, Giuseppina; Refojo, Damián; Giacomini, Damiana; Turck, Christoph W.; Holsboer, Florian; Arzt, Eduardo; Silberstein, Susana. B-Raf and CRHR1 Internalization Mediate Biphasic ERK1/2 Activation by CRH in Hippocampal HT22 Cells.

SIRT1 is significantly up-regulated in invasive ductal carcinoma relative to normal tissue adjacent to tumor, further suggesting a role of SIRT1 in breast cancer. Holloway, Kimberly R.; Barbieri, Andreia; Malyarchuk, Svitlana; Saxena, Madhurima; Nedeljkovic-Kurepa, Ana; Mehl, Mathieu Cameron; Wang, Allison; Gu, Xin; Pruitt, Kevin. SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression.

Beckers, Albert; Aaltonen, Lauri A.; Daly, Adrian F.; Karhu, Auli. Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene.

Moeller, Hanne B.; Rittig, Soren; Fenton, Robert A. Nephrogenic Diabetes Insipidus: Essential Insights into the Molecular Background and Potential Th erapies for Treatment.

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