The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at www.endocrine.org.
Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion • Masakazu Notsu, Toru Yamaguchi, Kyoko Okazaki, Ken-ichiro Tanaka, Noriko Ogawa, Ippei Kanazawa, and Toshitsugu Sugimoto • These findings indicate that, after cells become con uent, AGE3 partially inhibits the di erentiation and mineralization of osteoblastic cells by binding to RAGE and increasing TGF-β expression and secretion. ey also suggest that TGF-β adversely a ects bone quality not only in primary osteoporosis but also in diabetes-related bone disorder.
Impaired Preadipocyte Differentiation into Adipocytes in Subcutaneous Abdominal Adipose of PCOS-Like Female Rhesus Monkeys • Erica Keller, Gregorio D. Chazenbalk, Paul Aguilera, Vanessa Madrigal, Tristan Grogan, David Elashoff, Daniel A. Dumesic, and David H. Abbott • Early-to-mid gestational T excess in female rhesus monkeys impairs adult preadipocyte di erentiation to adipocytes in SC abdominal adipose and may constrain the ability of this adipose depot to safely store fat with age.
A Polymorphism in the Crhr1 Gene Determines Stress Vulnerability in Male Mice • Christiana Labermaier, Christine Kohl, Jakob Hartmann, Christian Devigny, Andre Altmann, Peter Weber, Janine Arloth, Carina Quast, Klaus V. Wagner, Sebastian H. Scharf, Ludwig Czibere, Regina Widner-Andrä, Julia Brenndörfer, R. Landgraf, Felix Hausch, Ken A. Jones, Marianne B. Müller, Manfred Uhr, Florian Holsboer, Elisabeth B. Binder, and Mathias V. Schmidt • The results suggest that patients with a specific genetic predisposition in the CRHR1 gene together with an exposure to chronic stress may benefit from a treatment selectively antagonizing CRHR1 hyperactivity.
Blunted Day-Night Changes in Luteinizing Hormone Pulse Frequency in Girls with Obesity: The Potential Role of Hyperandrogenemia • Jessicah S. Collins, Jennifer P. Beller, Christine Burt Solorzano, James T. Patrie, R. Jeffrey Chang, John C. Marshall, and Christopher R. McCartney • Day-tonight changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. is phenomenon may in part re ect hyperandrogenemia.
An Independent Study of a Gene Expression Classifier (Afirma™) in the Evaluation of Cytologically Indeterminate Thyroid Nodules • Bryan McIver, M. Regina Castro, John C. Morris, Victor Bernet, Robert Smallridge, Michael Henry, Laura Kosok, and Honey Reddi • The Afirma GEC demonstrates a lower than expected rate of benign reports in FN/ HCN, and a lower than anticipated malignancy rate within GEC-suspicious nodules. These data suggest that the Positive Predictive Value of the GEC is lower than previously reported and call into question the performance of the test when applied in the context of specialized Academic cytopathology.
The World Health Organization Fracture Risk Assessment Tool (FRAX) Underestimates Incident and Recurrent Fractures in Consecutive Patients with Fragility Fractures • Sophie Roux, François Cabana, Nathalie Carrier, Michèle Beaulieu, Pierre-Marc April, Marie-Claude Beaulieu, and Gilles Boire • The FRAX-BMI scores were below the Canadian threshold for treatment in more than half the patients at the time of a FF and in close to a third of patients with recurrent FF. FRAX-BMI severely underestimates the FF risk in patients younger than 65 years old and after a single FF.
Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans • Hae Yoon Choi, Sungeun Kim, Ji Woo Park, Nam Seok Lee, Soon Young Hwang, Joo Young Huh, Ho Cheol Hong, Hye Jin Yoo, Sei Hyun Baik, Byung-Soo Youn, Christos S. Mantzoros, and Kyung Mook Choi • Circulating irisin levels were not di erent in individuals with detectable BAT or those with sarcopenia compared to control subjects and were not correlated with skeletal muscle mass index.
Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans • David J. Hodson, Andrei I. Tarasov, Silvia Gimeno Brias, Ryan K. Mitchell, Natalie R. Johnston, Shahab Haghollahi, Matthew C. Cane, Marco Bugliani, Piero Marchetti, Domenico Bosco, Paul R. Johnson, Stephen J. Hughes, and Guy A. Rutter • Together, these findings suggest that GLP-1 alters beta cell intermediary metabolism to in uence ATP dynamics in a species-specific manner, and this may contribute to divergent regulation of the incretin-axis in rodents and man.
Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues • Rucha Patel, Jasmine Williams-Dautovich, and Carolyn L. Cummins • This review summarizes recent discoveries of tissue-selective modulators of glucocorticoid signaling that are important in mediating the unwanted side e ects of therapeutic glucocorticoid use, emphasizing the downstream molecular e ects of GR activation in the liver, adipose tissue, muscle, and pancreas.