The following studies, among others, will be published in Endocrine Society journals. Before print, they are edited and posted online in each journal’s Early Release section. You can access the journals at www.endo-society.org.
Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia Rita Basu, Cristina Barosa, John Jones, Simmi Dube, Rickey Carter, Ananda Basu, and Robert A. Rizza Elevated gluconeogenesis in the fasting state in IFG/NGT and impaired insulininduced suppression of both gluconeogenesis and glycogenolysis in IFG/IGT suggest that alteration in the regulation of these pathways occurs early in the evolution of type 2 diabetes.
Approach to the Cushing’s Disease Patient With Persistent/Recurrent Hypercortisolism After Pituitary Surgery Xavier Bertagna and Laurence Guignat Although it is the ideal treatment, pituitary surgery is not always successful, and success is not always lasting
Kinase Inhibitors: Adverse Effects Related to the Endocrine System Maya B. Lodish The use of kinase inhibitors (KIs) in the treatment of cancer has become increasingly common, and practitioners must be familiar with endocrine-related side effects associated with these agents.
Low- or High-Dose Radioiodine Remnant Ablation for Differentiated Thyroid Carcinoma: A Meta-Analysis Weiwei Cheng, Chao Ma, Hongliang Fu, Jianing Li, Suyun Chen, Shuqi Wu, and Hui Wang The low dose of 1100 MBq radioiodine activity is sufficient for thyroid remnant ablation as compared to 3700 MBq radioiodine activity with similar quality of life, less common adverse effects, and a shorter hospital stay
Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor Mohsin Syed, Michael Cozart, Anessa C. Haney, Noor Akhter, Angela K. Odle, Melody Allensworth-James, Christopher Crane, Farhan M. Syed, and Gwen V. Childs Leptin may optimize somatotrope function by facilitating expression of membrane GHRH receptors and the production or maintenance of GH stores.
Excess Androgen During Puberty Disrupts Circadian Organization in Female Rats Michael T. Sellix, Zachary C. Murphy, and Michael Menaker Excess androgen during puberty, a common feature of PCOS, negatively affects internal circadian organization in both the reproductive and metabolic axes.
The Androgen Metabolite, 5β-Androstane-3β,17β-Diol (3β-Diol), Activates the Oxytocin Promoter Through an Estrogen Receptor-β Pathway Ryoko Hiroi, Anthony F. Lacagnina, Laura R. Hinds, David G. Carbone, Rosalie M. Uht, and Robert J. Handa 3β-diol induces oxytocin promoter activity via ER-β–cHRE interactions.>
Conditional Mutagenesis of Gata6 in SF1-Positive Cells Causes Gonadal-Like Differentiation in the Adrenal Cortex of Mice Marjut Pihlajoki, Elisabeth Gretzinger, Rebecca Cochran, Antti Kyrönlahti, Anja Schrade, Theresa Hiller, Laura Sullivan, Michael Shoykhet, Erica L. Schoeller, Michael D. Brooks, Markku Heikinheimo, and David B. Wilson GATA6 regulates the differentiation of steroidogenic progenitors into adrenocortical cells.
Investigating New Therapeutic Strategies Targeting Hyperinsulinemia’s Mitogenic Effects in a Female Mouse Breast Cancer Model Ran Rostoker, Keren Bitton-Worms, Avishay Caspi, Zila Shen-Orr, and Derek LeRoith Targeting (even partially) both IR and IGF-IRs impairs hyperinsulinemia’s effects in breast tumor development while simultaneously sparing the metabolic abnormalities observed when targeting IR alone with virtual complete inhibition.
Androgens Promote Prostate Cancer Cell Growth Through Induction of Autophagy Yan Shi, Jenny J. Han, Jayantha B. Tennakoon, Fabiola F. Mehta, Fatima A. Merchant, Alan R. Burns, Matthew K. Howe, Donald P. McDonnell, and Daniel E. Frigo Androgens regulate overall cell metabolism and cell growth, in part, by increasing autophagy in prostate cancer cells.
Mutations in MCT8 in Patients with Allan-Herndon-Dudley-Syndrome Affecting Its Cellular Distribution Simone Kersseboom, Gert-Jan Kremers, Edith C. H. Friesema, W. Edward Visser, Wim Klootwijk, Robin P. Peeters, and Theo J. Visser MCT8 mutations in AHDS patients may have tissue-specific effects on TH transport probably caused by tissue-specific expression of yet unknown MCT8-interacting proteins.
Hanne B. Moeller, Søren Rittig, and Robert A. Fenton Nephrogenic Diabetes Insipidus: Essential Insights into the Molecular Background and Potential Therapies for Treatment