For the fifth year in a row, Endocrine News spoke with editors from Endocrine Society journals to get the scoop on the top endocrine discoveries of 2019. Here is part 6 of Eureka! 2019.
Journal of the Endocrine Society associate editor Bülent O. Yildiz, MD, professor at Hacettepe University School of Medicine in Ankara, Turkey, chose “E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero,” by Caron, K.M., et. al. also published in October, as his top JES pick of 2019.
“E-cigarette use or vaping is on a daunting rise, particularly in youth with a misperception that it is safe.”
Researchers exposed female mice to e-cigarette vapor resulting in delayed first pregnancy and possible fetal death. Furthermore, e-cigarette exposure in mating mice caused a delay in embryo attachment, and female offspring exposed to e-cigarettes in utero failed to grow to normal size at age 8.5 months. “E-cigarette use or vaping is on a daunting rise, particularly in youth with a misperception that it is safe,” remarks Yildiz.
“This study provides new evidence that vaping not only has unfavorable effects on a woman’s ability to conceive, but it may also adversely influence future health of the newborn, probably through genetic and epigenetic mechanisms,” he says.
Editor’s Note: A full-length feature devoted to this study will be published in an upcoming issue of Endocrine News.
Below are the studies from the “Eureka 2019!” article in the December Endocrine News:
Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity,” Singer, K., et. al. February 2019
“Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice,” Ryan, K.K., et. al. fMay 2019
“The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice,” Sudo, N., et. al. October 2019
“Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons,” Tsukamura, H., et. al. May 2019
“Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice,” Rissman, E.F., et. al. August 2019
“Gestational Diabetes Adversely Affects Pancreatic Islet Architecture and Function in the Male Rat Offspring,” Dolinsky, V.W., et. al. August 2019
“Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine,” Mahajan A., et al. July 2019
The Journal of Clinical Endocrinology & Metabolism
“Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese,” Wallis G.A. and Gonzalez J.T., et. al. October 2019
“DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors,” Picó A., et. al. April 2019
Journal of the Endocrine Society
“Depression in Nonclassical Hypogonadism in Young Men,” Korenman, S.G. November 2018
“Magnetic Resonance Imaging Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold,” Steinberg, G.R. and Morrison, K.M., et. al. October 2019
“E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero,” Caron K.M., et. al. October 2019
New England Journal of Medicine
“An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes,” Herold, K.C., et. al. August 2019