For the fifth year in a row, Endocrine News spoke with editors from Endocrine Society journals to get the scoop on the top endocrine discoveries of 2019. Here is part 5 of Eureka! 2019.
Journal of the Endocrine Society editor-in-chief J. Larry Jameson, MD, PhD, professor of medicine, dean of the Perelman School of Medicine, and executive vice president for the Health System at the University of Pennsylvania, in Philadelphia highlights “Magnetic Resonance Imaging Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold,” by Steinberg, G.R. and Morrison, K.M., et. al., from October.
“Brown adipose tissue (BAT) is an important source of thermogenesis and energy, particularly in response to cold. Studies in humans have been somewhat limited by appropriate methodologies,” Jameson says. Accordingly, researchers recruited 12 healthy young men between the ages of 18 to 29 years for a first visit during which body measurements were taken and a second comprising sequential cold and warm exposures and simultaneous magnetic resonance imaging (MRI). BAT was rapidly activated in response to cold, likely mediated by triacylglycerol lipolysis.
“Brown adipose tissue (BAT) is an important source of thermogenesis and energy, particularly in response to cold. Studies in humans have been somewhat limited by appropriate methodologies.”
“This study suggests that MRI techniques can provide measurements of BAT activity in humans,” Jameson says.
Below are the studies from the “Eureka 2019!” article in the December Endocrine News:
Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity,” Singer, K., et. al. February 2019
“Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice,” Ryan, K.K., et. al. fMay 2019
“The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice,” Sudo, N., et. al. October 2019
“Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons,” Tsukamura, H., et. al. May 2019
“Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice,” Rissman, E.F., et. al. August 2019
“Gestational Diabetes Adversely Affects Pancreatic Islet Architecture and Function in the Male Rat Offspring,” Dolinsky, V.W., et. al. August 2019
“Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine,” Mahajan A., et al. July 2019
The Journal of Clinical Endocrinology & Metabolism
“Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese,” Wallis G.A. and Gonzalez J.T., et. al. October 2019
“DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors,” Picó A., et. al. April 2019
Journal of the Endocrine Society
“Depression in Nonclassical Hypogonadism in Young Men,” Korenman, S.G. November 2018
“Magnetic Resonance Imaging Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold,” Steinberg, G.R. and Morrison, K.M., et. al. October 2019
“E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero,” Caron K.M., et. al. October 2019
New England Journal of Medicine
“An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes,” Herold, K.C., et. al. August 2019