For the fifth year in a row, Endocrine News spoke with editors from Endocrine Society journals to get the scoop on the top endocrine discoveries of 2019. Here is part 8 of Eureka! 2019.
From April, “DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors,” by Picó, A., et. al. was selected by The Journal of Clinical Endocrinology & Metabolism associate editor Anthony P. Heaney, MD, PhD, professor at the David Geffen School of Medicine at the University of California, in Los Angeles.
“Although pituitary tumors are very common, they are notable for the lack of traditional driver mutations found in other tumor types,” Heaney explains. The team of researchers used PCR to analyze the effect that deoxyribonucleic acid (DNA) methylation would have on expression of 35 tumor suppressor genes (TSGs) in 105 pituitary neuroendocrine tumors (PitNETs). Effects varied with PitNET subtypes.
“This study adds to existing knowledge that epigenetic deregulation, including DNA methylation, histone modification, nucleosome remodeling, and ribonucleic acid (RNA)-mediated targeting, plays a causative role in pituitary tumorigenesis,” Heaney says.
Below are the studies from the “Eureka 2019!” article in the December Endocrine News:
Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity,” Singer, K., et. al. February 2019
“Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice,” Ryan, K.K., et. al. fMay 2019
“The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice,” Sudo, N., et. al. October 2019
“Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons,” Tsukamura, H., et. al. May 2019
“Transgenerational Bisphenol A Causes Deficits in Social Recognition and Alters Postsynaptic Density Genes in Mice,” Rissman, E.F., et. al. August 2019
“Gestational Diabetes Adversely Affects Pancreatic Islet Architecture and Function in the Male Rat Offspring,” Dolinsky, V.W., et. al. August 2019
“Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine,” Mahajan A., et al. July 2019
The Journal of Clinical Endocrinology & Metabolism
“Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese,” Wallis G.A. and Gonzalez J.T., et. al. October 2019
“DNA Methylation of Tumor Suppressor Genes in Pituitary Neuroendocrine Tumors,” Picó A., et. al. April 2019
Journal of the Endocrine Society
“Depression in Nonclassical Hypogonadism in Young Men,” Korenman, S.G. November 2018
“Magnetic Resonance Imaging Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold,” Steinberg, G.R. and Morrison, K.M., et. al. October 2019
“E-Cigarette Exposure Delays Implantation and Causes Reduced Weight Gain in Female Offspring Exposed In Utero,” Caron K.M., et. al. October 2019
New England Journal of Medicine
“An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes,” Herold, K.C., et. al. August 2019